DNA Polymerase B1 Binding Protein 1 Is Important for DNA Repair by Holoenzyme PolB1 in the Extremely Thermophilic Crenarchaeon .

DNA polymerase B1 (PolB1) is a member of the B-family DNA polymerase family and is a replicative DNA polymerase in Crenarchaea. PolB1 is responsible for the DNA replication of both the leading and lagging strands in the thermophilic crenarchaeon . Recently, two subunits, PolB1-binding protein (PBP)1 and PBP2, were identified in .

PolB1 Is Sufficient for DNA Replication and Repair Under Normal Growth Conditions in the Extremely Thermophilic Crenarchaeon .

The thermophilic crenarchaeon has four DNA polymerases (DNAPs): PolB1, PolB2, PolB3, and Dbh (PolY). Previous studies suggested that PolB1 is the main replicative DNAP of whereas PolB2 and Y-family polymerases Dpo4 () or Dbh are involved in DNA repair and translesion DNA synthesis. On the other hand, there are various opinions about the role of PolB3, which remains to be clearly resolved.