Proposal for a Method to Measure the Range of Dart-Throwing Motion.

Purpose: To examine the reliability of a novel technique to measure the range of the dart-throwing motion.

Methods: Two raters measured the range of the dart-throwing motion in 40 healthy subjects. For the measurement, subjects were asked to perform a simulated hammering motion using various experimental tools (a real hammer, a thick wooden rod, and a thin wooden rod).

Test-retest reliability of goniometric measurements of the range of dart-throwing motion.

[Purpose] To examine the reliability of using a manual goniometer for measuring the range of dart-throwing motion. [Participants and Methods] The range of dart-throwing motion in 24 healthy participants was measured by three raters on the same day, and one rater repeated the measurement on another day of the same week. The stationary arm of the goniometer was placed along the radius, and the moveable arm was placed along the shaft of the second metacarpal, approximately 45° supinated from Lister's tubercle.

Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester.

Cholangiocarcinoma is markedly resistant to chemotherapy and has a dismal prognosis, but its mechanism of drug resistance is unknown. This study examines whether glutathione S-transferase-pi (GSTP1-1) is involved in resistance to anticancer drugs in cholangiocarcinoma and whether GSTP1-1-specific inhibitors can overcome this resistance. First, immunohistochemical examination disclosed strong staining of all our 17 cholangiocarcinoma specimens for GSTP1-1, irrespective of histological type.