Publications by authors named "Hirohiko Tsugane"
Selenoprotein P (SeP; encoded by SELENOP in humans, Selenop in rodents) is a hepatokine that is upregulated in the liver of humans with type 2 diabetes. Excess SeP contributes to the onset of insulin resistance and various type 2 diabetes-related complications. We have previously reported that the long-chain saturated fatty acid, palmitic acid, upregulates Selenop expression, whereas the polyunsaturated fatty acids (PUFAs) downregulate it in hepatocytes.
View Article and Find Full Text PDFLeukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that causes skeletal muscle insulin resistance. The circulating levels of LECT2 are a possible biomarker that can predict weight cycling because they reflect liver fat and precede the onset of weight loss or gain. Herein, to clarify the dynamics of this rapid change in serum LECT2 levels, we investigated the in vivo kinetics of LECT2, including its plasma half-life and tissue distribution, by injecting I-labelled LECT2 into ICR mice and radioactivity tracing.
View Article and Find Full Text PDFArticle Synopsis
- Dieting can cause weight cycling, where individuals repeatedly lose and regain weight, but there's limited knowledge on blood markers that indicate overnutrition during this process.
- Research found that serum leukocyte cell-derived chemotaxin 2 (LECT2) quickly changed in response to diet shifts in obese mice, decreasing when switching from a high-fat diet to a regular diet and increasing with the opposite switch.
- LECT2 levels in the blood correlated with liver triglyceride content, suggesting it could be a useful marker for managing obesity.