Publications by authors named "Hirohiko Kobayashi"
We report the first use of endoscopic submucosal dissection (ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus (EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus.
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- - A rare case of acute liver injury was reported in a 41-year-old man following treatment for internal hemorrhoids using a submucosal injection of aluminum potassium sulfate and tannic acid (ALTA) combined with lidocaine.
- - The liver injury was identified as hepatocellular and cholestatic, but the exact mechanism behind the injury couldn't be determined; high levels of eosinophils and immunoglobulin E were noted, while a lymphocyte stimulation test returned negative results after 25 days.
- - The patient's liver condition improved significantly after two weeks of fluid replacement therapy, highlighting the need for further analysis of similar cases in the future as this is the first reported severe liver disorder linked to ALTA treatment.
The morphogenesis of lobular restructuring to liver cirrhosis in nonalcoholic steatohepatitis (NASH) is yet to be clearly understood. Therefore, we observed tissue samples from three biopsies and one autopsy with NASH in the non-cirrhotic stage three-dimensionally to elucidate the evolution of fibrosis and the changes of angioarchitecture. Histologic reconstructions revealed that pericellular fibrosis developed around the central vein in the early stage and gradually progressed to arch-shaped band-like fibrosis connecting the central veins in the neighboring lobules.
View Article and Find Full Text PDFSphere formation has been utilized as a way to isolate multipotent stem/progenitor cells from various tissues. However, very few studies on bone marrow-derived spheres have been published and assessed their multipotentiality. In this study, multipotent marrow cell populations were isolated using a three-step method.
View Article and Find Full Text PDFRecent studies have indicated that bone marrow cells can regenerate damaged muscles and that they can adopt phenotypes of other cells by cell fusion. Our direct visualization system gave evidence of massive muscle regeneration by green fluorescent protein (GFP)-labeled CD45+c-Kit+Sca-1+Lin- cells (KSL cells), and we investigated the role of KSL cells in muscle regeneration after transplantation with or without lethal irradiation. In the early phase, GFP signals were clearly observed in all the muscles of only irradiated mice.
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