Clinical evaluation of direct composite versus zirconia resin-bonded fixed dental prostheses for a single missing anterior tooth: A short-term multicenter retrospective study.

Objectives: This study aimed to compare the outcome of a simplified direct composite resin-bonded fixed dental prostheses without reinforcing fibers (CR-RBFDP) and resin-bonded fixed dental prostheses using zirconia (Zr-RBFDP).

Methods: The clinical records of five private practice dental clinics and one university hospital were analyzed. Failure was defined as a RBFDP that was removed or remade for any reason.

The presence of rRNA sequences in polyadenylated RNA and its potential functions.

Accumulating evidence has shown that various lengths of ribosomal RNA (rRNA) sequences are widely present in polyadenylated RNA. This review article will discuss these polyadenylated rRNA containing transcripts (PART). PART are highly abundant and widely expressed in various tissues.

RNA oxidation: a contributing factor or an epiphenomenon in the process of neurodegeneration.

In the past decade, RNA oxidation has caught the attention of many researchers, working to uncover its role in the pathogenesis of neurodegenerative diseases. It has been well documented that RNA oxidation is involved in a wide variety of neurological diseases and is an early event in the process of neurodegeneration. The analysis of oxidized RNA species revealed that at least messenger RNA (mRNA) and ribosomal RNA (rRNA) are damaged in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

A novel noncoding RNA rescues mutant SOD1-mediated cell death.

Transgenic mice expressing mutant Cu2+/Zn2+ superoxide dismutase SOD1(G93A) develop similar clinical and pathological phenotypes to amyotrophic lateral sclerosis (ALS) patients. Here, we utilize representational difference analysis to identify the transcripts that are up-regulated in the presymptomatic stage of SOD1(G93A) mice. Unexpectedly, three predominant clones were 18S or 28S ribosomal RNA (rRNA) segments.

Effects of light intensity through resin inlays on the bond strength of dual-cured resin cement.

Purpose: To evaluate the influence of the light intensity, irradiation time, and thickness of the indirect restoration composite on the bond strength of dual-cured resin cement immediately after cementation, applying the resin coating technique.

Materials And Methods: Three hundred forty composite blocks as an adhesive surface and four thicknesses of indirect restoration composite disks were prepared. The surface of the composite blocks was coated with low-viscosity resin composite and immersed in water for 24 h.

The identification and characterization of oxidized RNAs in Alzheimer's disease.

It has been shown that cytoplasmic RNA oxidation occurs to a great extent in the brains of Alzheimer's disease (AD) patients. The goal of this study was to isolate and identify oxidized RNA species in AD. We show that significant amounts of poly(A)+ mRNAs are oxidized in AD brains.

Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase.

We examined the characteristic clinical features of one family of familial amyotrophic lateral sclerosis (FALS) with a His46Arg mutation in the enzyme Cu/Zn superoxide dismutase-1 (SOD1). The disease duration for this family was 18.1 +/- 13.