Publications by authors named "Hirofumi Sei"

Objective: We aimed to elucidate the dynamics of deglutition during head rotation by acquiring 320-row area detector computed tomography (320-ADCT) images and analyzing deglutition during head rotation.

Methods: This study included 11 patients experiencing globus pharyngeus. A 320-ADCT was used to acquire images in two types of viscosity (thin and thick), with the head rotated to the left.

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Background: Tracheostomy is an important procedure for the treatment of severe coronavirus disease-2019 (COVID-19). Older age and obesity have been reported to be associated with the risk of severe COVID-19 and prolonged intubation, and anticoagulants are often administered in patients with severe COVID-19; these factors are also related to a higher risk of tracheostomy. Cricotracheostomy, a modified procedure for opening the airway through intentional partial cricoid cartilage resection, was recently reported to be useful in cases with low-lying larynx, obesity, stiff neck, and bleeding tendency.

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Objectives: Laryngeal complications have been reported after endotracheal intubation and prone positioning in patients with critical coronavirus disease 2019 (COVID-19), but their association is unclear. In this study, we investigated the rate of laryngeal complications in patients with COVID-19 compared to an alternative condition (control group).

Methods: We retrospectively analyzed the data of 40 patients who underwent endotracheal intubation for either COVID-19 or an alternative condition (control group).

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Simple methods, such as the line spread test (LST), are often used to evaluate thickened liquids in clinical settings. Although it is desirable for these simple methods to be rapid, even the LST requires approximately 1 min to complete the evaluation. Herein, we aimed to shorten this time by developing a new simple instrument for evaluating thickened liquids considering the fluid engineering perspective with improved funnel design and evaluation methods.

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A case of laryngeal actinomycosis occurred after bone marrow transplantation was reported. The patient was a 14-year-old girl who had a history of bone marrow transplantation for the treatment of acute lymphocytic leukemia 4month before the onset of the disease. She was referred to our hospital complaining persistent sore throat since 2weeks ago.

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Conclusion: Bortezomib was effective in attenuating atrophy of the posterior cricoarytenoid (PCA) muscle, but not the thyroarytenoid (TA) muscle. This was probably due to differences in the fiber composition of the two muscles. The PCA muscle is composed of a combination of fast- and slow-twitch fibers, and therefore is more resistant to atrophy than the TA muscle, which is composed solely of fast-twitch fibers.

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Article Synopsis
  • The study investigated how three transcription factors (FOXO3a, P-FOXO3a, and PGC-1α) change during laryngeal muscle atrophy after nerve damage in Wistar rats.
  • It found that the intrinsic laryngeal muscles showed significant weight loss and muscle fiber changes more quickly in the thyroarytenoid (TA) muscle compared to the posterior cricoarytenoid (PCA) muscle.
  • Results indicated that muscle atrophy correlates with FOXO3a and PGC-1α expression changes, suggesting these factors play a significant role in the process.
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