Secondary malignant fibrous histiocytoma following refractory langerhans cell histiocytosis.

We describe a rare case of secondary malignant fibrous histiocytoma (MFH) following Langerhans cell histiocytosis (LCH). A 23-year-old Japanese male exhibited systemic lymphadenopathy, multiple lung tumors, and osteolytic changes in bilateral iliac bones in 1989. A biopsy specimen from the left iliac bone revealed an infiltration of S-100 protein-positive histiocyte-like cells intermingled with eosinophils, which confirmed the diagnosis of eosinophilic granuloma, a type of LCH.

A comparison of the specificity and sensitivity of two Candida antigen assay systems for the diagnosis of deep candidiasis in patients with hematologic diseases.

Background: Latex agglutination assay for detection of circulating Candida antigen (Cand-Tec, Ramco Laboratories), which is now commercially available, provides a rapid and simple means for the diagnosis and management of deep-seated Candida infections.

Material/methods: The Cand-Tec microtiter system (Cand-Tec MT, Ramco Japan), new latex agglutination assay for Candida antigen, expresses Candida antigen level as the cutoff index (C.I.

An autopsy case of disseminated mucormycosis in a neutropenic patient receiving chemotherapy for the underlying solid malignancy.

Mucormycosis is a rare, opportunistic infection caused by fungi of the order Mucorales, class Zygomycetes. These fungi produce fatal opportunistic infections in immunocompromised patients, especially in those with severe neutropenia. Recently, mucormycosis has become more widespread, because potent, myelosuppressive chemotherapies are performed more often than before.