Publications by authors named "Hirofumi Akiyama"
A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic rare actinomycete of the genus Streptosporangium, was isolated from the culture extract of a thermophilic actinomycete Actinomadura sp. The complete H and C NMR assignment and absolute configuration of 1 were addressed by spectroscopic measurements including NOESY and CD spectra coupled with ECD calculation, which allowed to establish the (5 R,9 S,10 R,13 S)-configuration. Compound 1 was moderately cytotoxic against P388 murine leukemia cells with IC 30 μM.
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- Two new furanone-containing compounds, linfuranones B and C, were discovered from a plant-associated actinomycete called Sphaerimonospora.
- Their structures were analyzed using NMR and MS techniques, with their configurations determined through various chemical methods.
- Both linfuranones B and C promoted the differentiation of preadipocytes into mature fat cells at concentrations of 20-40 μM, without causing any cell toxicity.