Publications by authors named "Hiroe Kato"

Cells sense and integrate multiple signals to coordinate a response. A receptor-kinase signaling pathway for plant stomatal development shares components with the immunity pathway. The mechanism ensuring their signal specificities remains unclear.

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Article Synopsis
  • Selective manipulation of protein interactions with chemical compounds can help understand and control plant development processes, particularly the differentiation of stomata, which are crucial for plant growth.
  • The study introduces Stomidazolone, a unique compound that binds to the MUTE protein—a key regulator of stomatal differentiation—and disrupts its interaction with another protein, SCREAM.
  • Through structural modeling and engineering, the researchers created modified MUTE proteins that resist Stomidazolone, demonstrating a method to potentially control stomatal development in plants.
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Article Synopsis
  • Cells coordinate development and defense by sensing multiple signals, and a specific pathway for plant stomatal development is connected to the immunity pathway, although the details of this connection are unclear.
  • Researchers discovered a small molecule, kC9, that promotes excessive stomatal differentiation by inhibiting a key receptor-kinase pathway, specifically targeting the MAP kinase MPK6.
  • Interestingly, activating immune signaling with a bacterial peptide can counteract kC9's effects on stomatal development, revealing that the interplay between developmental and immune signals is managed by receptor availability and helps maintain signal specificity.
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Introduction: In patients with combined lumbar spinal canal stenosis (LSCS), a herniated intervertebral disc (IVD) that compresses the dura mater and nerve roots is surgically treated with discectomy after laminoplasty. However, defects in the IVD after discectomy may lead to inadequate tissue healing and predispose patients to the development of IVD degeneration. Ultrapurified stem cells (rapidly expanding clones (RECs)), combined with an in situ-forming bioresorbable gel (dMD-001), have been developed to fill IVD defects and prevent IVD degeneration after discectomy.

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The increasing climate changes and global warming are leading to colossal agricultural problems such as abatement of food production and quality. As stomatal development is considered to play a key role in crop plant productivity and water-use efficiency, studying stomatal development is useful for understanding the productivity of plant systems for both natural and agricultural systems. Herein, we report the first-in-class synthetic small molecules enhancing the number of stomata in Arabidopsis thaliana that have been discovered by screening of the chemical library and further optimized by the Pd-catalyzed C-H arylation reaction.

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