Real-world data on combination treatment with bedaquiline in patients with multidrug-resistant pulmonary tuberculosis in Japan: An interim analysis of post-marketing surveillance.

Background: An observational post-marketing surveillance (PMS) is being conducted to evaluate the long-term safety and effectiveness of bedaquiline as part of combination therapies in treating pulmonary multidrug-resistant tuberculosis (MDR-TB) in Japan.

Methods: This interim analysis includes patients with MDR-TB who started bedaquiline-containing anti-tuberculosis (TB) drugs in Japan between January 2018 and September 2022. Outcomes include the incidence of adverse drug reactions (ADRs) and negative sputum cultures.

FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR-SCREEN Database Study.

Advanced/metastatic urothelial cancer (a/m UC) still has a poor prognosis despite the recent medical advances. Recent studies demonstrated that fibroblast growth factor receptor (FGFR) gene alterations (GAs) may be driver genes for UC; however, the proportion of UC genetic panel testing in Japan remains low. We clarified the proportion of patients with FGFR2/3 GAs, treatment patterns, and clinical outcomes in a/m UC patients in Japan.

Perceptions and Responses to Diseases among Patients with Inflammatory Bowel Disease: Text Mining Analysis of Posts on a Japanese Patient Community Website.

Introduction: Patients with inflammatory bowel disease (IBD) are increasingly using online platforms to communicate with other patients and healthcare professionals seeking disease-related information and support. Free-text posts on these platforms could provide insights into patients' everyday lives, which could help improve patient care. In this proof-of-concept (POC) study, we applied text mining to extract patient needs from free-text posts on a community forum in Japan, holistically visualized the patients' perceptions and their connections, and explored the patient characteristic-dependent trends in the use of words.

TiO nanotubes with customized diameters for local drug delivery systems.

In this study, we evaluated the drug release behavior of diameter customized TiO nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two-diameter]), and a 20-60 V swept potential (49 nm [full-tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two-diameter) and 49 nm (full-tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two-diameter), 49 nm (full-tapered), and 45 nm samples.

Efficacy of golimumab in rheumatoid arthritis patients at high risk of a poor prognosis: Post hoc analysis of GO-FORTH study using cluster analysis.

Objectives: Our objective was to assess the efficacy of golimumab (GLM) in patients with poor prognostic factors (PPFs).

Methods: This is a post hoc analysis of GO-FORTH Phase 2/3 study. Cluster analysis was used to determine a patient population with high-risk patterns based on seven PPFs suggested by the European Alliance of Associations for Rheumatology recommendations and limited physical function.

Safety and Effectiveness of Ustekinumab for Crohn's Disease in Japanese Post-marketing Surveillance in Biologic-Naive and -Experienced Conriemed.

Background: To present the real-world evidence on the safety and effectiveness of ustekinumab (UST) through 52-week treatment for Crohn's disease (CD) under an analysis of post-market surveillance data in Japan.

Methods: This prospective, post-marketing surveillance study was conducted in 341 patients from 91 medical facilities in Japan. Patients received UST 90 mg injected subcutaneously once every 12 weeks (or every 8 weeks if patients show weak effectiveness) after an induction dose given intravenously.

Band structures of passive films on titanium in simulated bioliquids determined by photoelectrochemical response: principle governing the biocompatibility.

The band structures and band gap energies, , of passive films formed on titanium (Ti) in simulated bioliquids, Hanks' solution (Hanks) and saline, were evaluated. Ti was polarized at 0, -0.1, and -0.

Real-world data for golimumab treatment in patients with ulcerative colitis in Japan: interim analysis in post-marketing surveillance.

Background/aims: Golimumab (GLM) is an anti-tumor necrosis factor-α drug approved for treating moderate-to-severe active ulcerative colitis (UC). A 52-week post-marketing surveillance (PMS) was initiated to evaluate its safety and effectiveness in patients with UC in Japan. We present an interim report of the ongoing PMS.

Less known facts and findings about TiO nanotubes.

Anodic TiO nanotubes that are grown on Ti substrates by a simple anodization in various types of fluoride containing electrolytes have attracted scientific and technological interest due to their wide potential applications, and therefore, numerous research efforts have been dedicated to these self-ordered oxide structures in the past decade. The present mini-review highlights less known but important aspects, such as the formation of spaced nanotubes with adjustable interspacing that is achieved in a few specific organic electrolytes, and strong effects of the metallic Ti substrate which significantly affect the growth of the tubes. We discuss the formation of oxide nanotubes grown from adequately alloyed substrates and noble metal nanoparticle decoration of tubes.

Degradation of Ti-6Al-4V alloy under cyclic loading in a simulated body environment with cell culturing.

The present study reports the corrosion fatigue of the Ti-6Al-4V alloy using cyclic deformation test in a simulated body fluid under cell culturing for the first time. Cyclic deformation tests were carried out using three types of specimens to reveal the effects of proteins and cells on the corrosion fatigue of the alloy. For the 1-day-immersed and 1-week-immersed specimens, tensile specimens were soaked in a simulated body fluid for 1 day and 1 week, respectively, before cyclic deformation test, whereas for the cell-cultured specimen, MC3T3-E1 osteoblast-like cells were seeded and then cultured on tensile specimens for 1 week.

Self-organized cobalt fluoride nanochannel layers used as a pseudocapacitor material.

Aligned CoF2 nanochannel layers have been formed by self-ordering electrochemical anodization. In voltammograms these layers provide multiple oxidation states, an almost ideal rectangular pseudocapacitive behavior, a high specific capacitance and good capacitance retention. These layers may thus be promising for supercapacitor applications.

Self-organized nano-tubes of TiO2-MoO3 with enhanced electrochromic properties.

Self-organized TiO(2)-MoO(3) composite oxide nano-tubes with tunable dimensions are successfully fabricated by anodization of a Ti-Mo alloy and these nano-tube layers exhibit a significantly enhanced electrochromic color contrast compared with plain TiO(2) nano-tubes.

Microtensile bond strengths of single-step self-etch adhesive systems to bovine dentin.

The purpose of this study was to examine the microtensile bond strength of a single-step self-etch adhesive system (Clearfil tri-S Bond and One-Up Bond F Plus) to bovine dentin. Adhesive was applied to a flat dentin surface, and resin composite was bonded according to the manufacturers' instructions. After 24 h storage in distilled water at 37 degrees C, hourglass-shaped specimens were produced.