Publications by authors named "Hiroaki Tagaya"
Article Synopsis
- Chromosomal issues with the ALK gene occur in about 4% of non-small cell lung cancer patients, and while ALK tyrosine kinase inhibitors (ALK-TKIs) help, resistance mutations often emerge.
- The study aimed to create a PCR-based system to predict these resistance mutations and find effective second-line treatments using new ALK-TKIs like repotrectinib and ensartinib for patients who relapse after alectinib.
- Results showed that the developed system identified resistance mutations and suggested that the next-generation ALK-TKI TPX-0131 and the FLT3 inhibitor gilteritinib could be effective against repotrectinib and ensartinib-resistant mutations, leading
Background: To obtain a deep understanding of the mechanism by which breast cancer develops, the genes involved in tumorigenesis should be analyzed in vivo. Mouse mammary gland can regenerate completely from a mammary stem cell (MaSC), which enables us to analyze the effect of gene expression and repression on tumorigenesis in mammary gland regenerated from genetically manipulated MaSCs. Although lentiviral and retroviral systems have usually been applied for gene transduction into MaSCs, they are associated with difficulty in introducing long, repeated, or transcriptional termination sequences.
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