Publications by authors named "Hiroaki Kobayashi"

: This study aims to evaluate and compare the safety and efficacy of the da Vinci Xi and hinotori™ SRS robot-assisted surgical systems for gynecologic disorders. : We conducted a retrospective study of 401 cases (43 benign uterine tumors; 88 pelvic organ prolapses; 270 low-risk endometrial cancers) of robot-assisted surgery performed at Kagoshima University Hospital between January 2017 and October 2024. Surgical factors such as the operative time, blood loss, and complication rates were analyzed and compared between the da Vinci Xi (332 cases) and hinotori™ SRS (69 cases) systems.

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Sodium croconate, a high-voltage organic cathode material, can be applied to high-energy-density and cost-effective organic sodium-ion batteries (OSIBs) as an alternative to traditional lithium-ion batteries. However, organic molecular cathodes generally dissolve into the electrolyte, leading to poor cyclability. Thus, an electrolyte that can address the present limitations and further facilitate the fabrication of highly reversible OSIBs must be developed.

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An 87-year-old man with complaints of palpitations and digestive bleeding previously visited another hospital. He was referred to our hospital because of anemia. Small bowel endoscopy revealed an elevated lesion with bleeding from the ileum.

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Introduction: To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid-based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) were explored.

Methods: The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN/PEM between August 2018 and March 2024.

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Background: The standard for robotic para-aortic lymphadenectomy has not been fully established. Para-aortic lymphadenectomy performed by sharing the same ports with pelvic procedures, a procedure known as dual-docking surgery, can be performed using the latest robotic system. We prospectively examined the ability of standardized dual-docking robotic surgery in endometrial cancer patients.

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Objectives: This study aimed to compare the surgical outcomes of simple hysterectomy with sentinel lymph node biopsy for low-risk endometrial cancer performed using the hinotori™ Surgical Robot System and the da Vinci® Xi system.

Materials And Methods: We retrospectively analyzed the data of 234 patients who underwent simple hysterectomy with sentinel lymph node biopsy at Kagoshima University Hospital between January 2017 and June 2024. Amongst them, 20 patients underwent surgery using the hinotori™ Surgical Robot System and 214 using the da Vinci® Xi.

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  • Microcell-mediated chromosome transfer (MMCT) is a new technique for manipulating chromosome numbers using human induced pluripotent stem cells (hiPSCs) to create disease models with hyperaneuploidy.
  • The study highlights the efficiency of using hiPSCs as both donor and recipient cells in the chromosome transfer process, allowing for the tagging and transfer of specific chromosomes like Chr21 and ChrY using CRISPR-Cas9.
  • This innovative method aims to improve the study of rare diseases and enhance our understanding of early development by integrating key chromosomal regions into hiPSCs.
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infection has been associated with various systemic diseases and may cause delayed healing of muscle injury. However, the relationship between muscle injury healing and infection remains unclear. Our hypothesis was that infection delays the healing of muscle injuries.

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Rechargeable aqueous zinc-ion batteries (RAZIBs) are attracting increasing attention due to their advantages in safety, cost, and energy density. However, the choice of electrode binders when using aqueous electrolytes faces many constraints, as nontoxic and low-cost hydrophilic binders, such as sodium alginate (SA), can lead to electrode damage due to excessive swelling in aqueous solution. Here, by employing double-network hydrogel electrolytes formed by poly(vinyl alcohol) and alginate, the content and activity of water molecules at the electrode-electrolyte interface are reduced, and the mechanical stability of the electrode is reinforced, thereby affording reliable protection to the cathode bonded with SA.

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  • The study aimed to assess the effectiveness and safety of robot-assisted radical hysterectomy (RARH) in treating cervical cancer, comparing it to traditional surgical methods.
  • A total of 100 patients underwent RARH, achieving a high success rate with minimal blood loss and low recurrence rates after 2 years.
  • Results showed strong oncological outcomes, with RARH yielding excellent recurrence-free survival (RFS) and overall survival (OS) rates, suggesting its viability as a surgical option for cervical cancer.
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Malignant peripheral nerve sheath tumors (MPNSTs) of the cervix are rare, particularly in patients with neurofibromatosis type 1 (NF1). This report describes a cervical MPNST in an 18-year-old patient with no history of sexual activity, abnormal vaginal discharge, and prolonged menstruation. She had more than six café-au-lait spots on her body since birth and was diagnosed with NF1 at 2 years of age.

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  • Androgens have been key in prostate cancer (PCa) treatment for over 80 years, but advanced forms like castration-resistant and neuroendocrine PCa remain challenges, highlighting the need for new diagnostics and therapies.
  • The review focuses on two main aspects: the mechanisms of androgen receptor (AR) signaling pathways and the tumor microenvironment, revealing insights into gene regulation and genetic alterations for precision medicine.
  • Advanced research techniques, such as liquid biopsy and single-cell RNA sequencing, are enhancing our understanding of PCa's complexity, emphasizing the importance of personalized medicine and innovative treatment approaches.
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Phosphoglyceride crystal deposition disease is a rare condition occurring in soft tissues, resulting in scarring and affecting the bones, making preoperative differentiation from malignant tumors challenging. Here, we describe a case of phosphoglyceride crystal deposition disease initially suspected to be a malignant ovarian tumor before surgery. A 50-year-old woman with a history of three cesarean sections presented with lower abdominal pain.

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  • * Conducted in two steps, the research verifies optimum sample storage conditions and compares HPV test results from self-collected urine and vaginal samples with traditional clinician-collected cervical samples among 121 participants.
  • * Results show that while urine samples had lower HPV detection rates, the testing methods exhibited varying degrees of concordance, with self-collected vaginal samples showing better agreement with cervical testing compared to urine.
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Purpose: Stress urinary incontinence is a postoperative complication occurring in patients with pelvic organ prolapse (POP). Although the 1-hour pad test measures the degree of urinary incontinence qualitatively and quantitatively, some elderly women undergoing POP surgery do not have the daily activities of living to perform the pad test. Therefore, we examined whether the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) could be used as an alternative tool for pad tests.

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  • Recent studies have shown that higher levels of blood calciprotein particles (CPP) are linked to vascular calcification and cardiovascular issues in patients on hemodialysis, despite varying levels among individuals with similar phosphorus levels.
  • This study examined whether the ratio of serum CPP to serum phosphate (CPP/Pi ratio) could better predict cardiovascular events compared to traditional calcification tests (T) in 174 new hemodialysis patients.
  • Results indicated that the CPP/Pi ratio was a significant independent predictor of major heart and brain-related events, whereas traditional calcification propensity tests did not show a similar association.
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Background: Prognostic predictors of immunotherapy in patients with advanced endometrial cancer remain unclear. The potential role of inflammatory predictors, including pretreatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and hemoglobin, albumin, lymphocyte and platelet scores, was investigated.

Methods: Between August 2018 and December 2023, 35 patients were retrospectively analyzed.

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Background: Sentinel lymph node navigation surgery, which identifies the sentinel lymph node in early cervical cancers and omits systemic pelvic lymphadenectomy in cases where no lymph node metastasis is present, has recently gained attention. However, there are few reports on lymph node recurrence and the long-term outcomes of cervical cancer surgery performed using sentinel lymph node navigation surgery. In this study, we aimed to evaluate the long-term outcomes of sentinel node navigation surgery for early-stage cervical cancer.

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  • Cabozantinib is effective for advanced renal cell carcinoma (RCC), but 60% of patients experience severe side effects requiring dose reductions; this study examines its impact in Japanese patients.
  • Researchers measured cabozantinib trough concentrations in 10 Japanese RCC patients, finding higher concentrations correlated with better cancer control and increased adverse events.
  • Results suggest monitoring cabozantinib levels could enhance treatment effectiveness and reduce serious side effects in Japanese patients with RCC.
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  • * He was first treated with a chest tube for his right hemopneumothorax before being transferred to another hospital for emergency surgery.
  • * During surgery, doctors removed the metal fragment and a large amount of blood from his thoracic cavity; later imaging revealed cerebral infarctions linked to his hemorrhagic shock, despite no clots being found.
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Although exploratory laparoscopy in patients with advanced ovarian cancer is a diagnostic tool for determining treatment strategy, its safety has not been completely investigated. We report a case involving a severe abdominal abscess following an exploratory laparoscopy. A 65-year-old woman with advanced ovarian cancer developed a large abdominal abscess following exploratory laparoscopy and neoadjuvant chemotherapy.

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Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining.

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Radical cystectomy after low anterior resection is rare, and no cases of robotic surgery have been reported. Cystectomy in patients who have undergone a previous pelvic surgery, whether open or endoscopic, requires caution to avoid damaging other organs due to anatomical changes caused by adhesions in a limited space. Additionally, the curative nature of the treatment must be maintained.

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Introduction: NSCLC is a leading cause of cancer-related mortality worldwide. Specific genetic alterations, such as exon 14 (ex14) skipping, have been identified in NSCLC, allowing targeted therapy. Tepotinib, a highly selective MET inhibitor, has displayed promise in patients with advanced NSCLC.

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  • This study focuses on the incidence and prevalence of stuttering in 3-year-old children in Japan, as few studies have examined this disorder in the country.
  • A questionnaire was used on 2,055 children to screen for stuttering, with positive cases confirmed through interviews and assessments by professionals.
  • The findings showed a prevalence of 6.5% for current stuttering and 8.9% when accounting for past stuttering, with higher risks associated with family history and concerns about the child's development.
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