Publications by authors named "Hiroaki Itatani"

Objective: We analyzed the efficacy of ethinylestradiol as estrogen therapy on Castration-resistant Prostate Cancer (CRPC).

Patients And Methods: The study was conducted on 14 patients who were diagnosed as having CRPC and who were being prescribed ethinylestradiol (1.5-2.

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Article Synopsis
  • * A total of 32 patients (mostly older men) underwent a bladder-sparing protocol, with an 84.4% success rate in preserving the bladder post-treatment and a cancer-specific survival rate of 66.9% after five years.
  • * The researchers found a significant correlation between the presence of Bcl-x protein and lower cancer-specific survival rates, indicating its potential role as a prognostic marker in treatment outcomes.
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Article Synopsis
  • Chemoradiation therapy (CRT) is an effective bladder-preserving treatment for muscle-invasive bladder cancer (MIBC), but predicting patient response is crucial to avoid missing opportunities for cure through cystectomy.
  • The study explored the relationship between the ERCC1 gene and CRT resistance in bladder cancer, using various cell lines to measure ERCC1 levels and treatment efficacy.
  • Results showed that higher ERCC1 expression correlated with worse CRT outcomes, suggesting that ERCC1 levels could help predict treatment effectiveness in MIBC patients.
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Sorafenib is a multikinase inhibitor that is used for the treatment of metastatic renal-cell carcinoma. We report the case of a patient with painless acute pancreatitis associated with sorafenib treatment. The patient was a 71-year-old man who had undergone surgery for left renal carcinoma and tumor thrombus in the inferior vena cava and right atrium (IVC-RA).

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Purpose: We retrospectively reviewed 107 patients of upper urinary tract carcinoma to determine the overall outcome, prognostic factors, frequency of subsequent bladder cancer and role of adjuvant therapy.

Materials And Methods: 107 patients of upper urinary tract carcinoma, who underwent surgical treatment at Sumitomo Hospital between January 1992 and June 2007 were reviewed. The Kaplan-Meier method and Cox's proportional hazard model were used.

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A 65-year-old man with left renal cell carcinoma RCC underwent hand-assisted laparoscopic nephrectomy. He was discharged on the 8th hospital day, but 2 days later he was admitted to the hospital again because of vomiting and abdominal pain. Abdominal computed tomography (CT) showed a narrow space between the superior mesenteric artery (SMA) and aorta as well as distension of the proximal duodenum.

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A 60-year-old man underwent retroperitoneal laparoscopic nephrectomy for left renal tumor (cT1bN0M0).The histopathological examination revealed Kidney cancer grade 3 pT1b. The following evaluations revealed multiple bone metastasis.

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We report four patients with pancreatic metastasis of renal cell carcinoma who were successfully treated with radiation therapy. The patients were one woman and three men with a median age of 55 years (range, 49 to 62 years) who underwent radical nephrectomy for primary renal cell carcinoma. The median interval from nephrectomy to the diagnosis of pancreatic metastasis was 129 months (range, 54 to 176 months).

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A 42-year-old male was referred to our hospital with a complaint of right lumbar pain in September 1999. Abdominal computed tomography and magnetic resonance imaging revealed a large retroperitoneal tumor adjacent to the aorta and the renal vessels. We judged that it was inoperable.

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Although Castleman's disease may occur in any lymph node of the body, it is the most commonly found in the thoracic cavity. Castleman's disease rarely occurs in the pelvic cavity and only 18 such cases have been reported. We report a case of pelvic Castleman's disease.

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Here we report a rare case of inflammatory myofibroblastic tumor of the bladder. The patient was a 72-year-old man. We diagnosed this case preoperatively as urachal tumor from urine cytology, cystoscopy, and magnetic resonance imaging.

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Two cases of synchronous ipsilateral renal cell carcinoma and renal pelvic transitional cell carcinoma are presented, one in a 70-year-old man and another in a 54-year-old man. These two cases were diagnosed preoperatively as synchronous ipsilateral renal tumor and pelvic tumor from urine cytology, retrograde pyelography, computed tomography and magnetic resonance imaging, and in both two cases, nephroureterectomy was performed. Pathological diagnosis was renal cell carcinoma and renal pelvic transitional cell carcinoma, which existed incidentally in the same kidney.

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A 60-year-old male, who had been maintained on hemodialysis for 4 years, visited our hospital to receive living renal transplantation. He complained of macrohematuria, and preoperative examination showed elevation of psostate specific antigen (PSA). Cystoscopy revealed papillary tumors on the right lateral bladder wall.

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A 57-year-old male was referred to our hospital with a complaint of dizziness. Abdominal computed tomography and retrograde pyelography revealed a left renal tumor associated with hydronephrosis due to pelviureteric junction (PUJ) obstruction. A radical nephrectomy was performed and histological diagnosis was renal cell carcinoma.

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A 57-year-old man showed high serum cortisol, plasma adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) levels with a large pituitary tumor and a prostatic cancer. High dose dexamethasone did not suppress cortisol secretion and CRH administration did not stimulate cortisol secretion. After surgical removal of the pituitary tumor, plasma CRH, ACTH and serum cortisol levels were normalized.

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