Publications by authors named "Hiroaki Ishihata"

Knowledge regarding cancer stem cell (CSC) morphology is limited, and more extensive studies are therefore required. Image recognition technologies using artificial intelligence (AI) require no previous expertise in image annotation. Herein, we describe the construction of AI models that recognize the CSC morphology in cultures and tumor tissues.

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Background/aim: This study aimed to automate the classification of cells, particularly in identifying apoptosis, using artificial intelligence (AI) in conjunction with phase-contrast microscopy. The objective was to reduce reliance on manual observation, which is often time-consuming and subject to human error.

Materials And Methods: K562 cells were used as a model system and apoptosis was induced following administration of gamma-secretase inhibitors.

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Artificial intelligence (AI) technology for image recognition has the potential to identify cancer stem cells (CSCs) in cultures and tissues. CSCs play an important role in the development and relapse of tumors. Although the characteristics of CSCs have been extensively studied, their morphological features remain elusive.

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Deep learning is being increasingly applied for obtaining digital microscopy image data of cells. Well-defined annotated cell images have contributed to the development of the technology. Cell morphology is an inherent characteristic of each cell type.

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