Publications by authors named "Hiro-taka Masuda"
Article Synopsis
- A (3-aminopropyl)triethoxysilane-treated glass surface significantly enhances the coating with extracellular matrix (ECM) proteins compared to untreated glass, making it a better substrate for cell culture.
- When cultured on untreated glass, MDCK cells remove the coated ECM proteins and secrete their own, while on silanized glass, they retain the coated ECM.
- Cells on silanized glass display different morphology and higher motility, especially when coated with laminin instead of fibronectin, suggesting silanized glass is more effective for studying ECM effects on cell behavior.
Heterochromatin protein 1 (HP1) has an essential role in heterochromatin formation and mitotic progression through its interaction with various proteins. We have identified a unique HP1alpha-binding protein, POGZ (pogo transposable element-derived protein with zinc finger domain), using an advanced proteomics approach. Proteins generally interact with HP1 through a PxVxL (where x is any amino-acid residue) motif; however, POGZ was found to bind to HP1alpha through a zinc-finger-like motif.
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