Publications by authors named "Hiro-o Matsushita"
Article Synopsis
- The study aimed to evaluate the long-term outcomes, specifically overall survival (OS), of patients with T1 colorectal cancer (CRC) who underwent endoscopic resection (ER) followed by additional surgery (AS) compared to those who had primary surgery (PS) alone.
- It involved analyzing data from 6,105 patients treated at various high-volume Japanese institutions and utilized propensity score matching to ensure comparability between the two groups.
- The findings suggested that patients who underwent AS after ER had a 5-year OS rate of 97.1%, comparable to 96.0% for the PS group, indicating that ER before AS does not adversely affect long-term outcomes.
Article Synopsis
- The study aimed to assess the effectiveness of pathological criteria from the JSCCR guidelines for determining the need for additional treatment in patients with pT1 colorectal carcinoma who had undergone local resection.
- Researchers analyzed data from 4,667 patients and found that those with risk factors for lymph node metastasis had a significantly higher incidence of metastasis and recurrence, while those without risk factors had excellent survival rates.
- Overall, the findings support the JSCCR criteria, highlighting their importance in identifying low-risk patients who can expect favorable outcomes post-resection.
Article Synopsis
- The study investigates the impact of skipping additional surgery after local excision in patients with high-risk T1 colorectal cancer, questioning the need for invasive procedures when outcomes are similar.
- Analyzing data from 1975 patients, the research matches 401 pairs to compare those who underwent extra surgery with those who didn’t.
- Findings show that while the need for additional surgery resulted in slightly better overall survival rates, the LE-alone group experienced few complications and strong cancer-specific survival, highlighting the importance of tailored treatment plans.
Objectives: The whole picture of the disturbance in endoscopy performance caused by the coronavirus disease 2019 (COVID-19) pandemic in Japan remains to be clarified. Therefore, the Japan Gastroenterological Endoscopy Society-Tohoku conducted this questionnaire survey in Tohoku region of Japan.
Methods: A questionnaire on the number of diagnostic endoscopy procedures and resulting diagnosed cancers in 2019 and 2020 was sent to all guidance/guidance cooperation hospitals in the Japan Gastroenterological Endoscopy Society who worked in the Tohoku region.
We recently reported the decrease in the number of gastrointestinal (GI) cancer diagnoses in 2020 due to disturbance of the healthcare system by the coronavirus disease 2019 (COVID-19) pandemic, using a hospital-based cancer registration system in Akita prefecture, Japan. In this study, we extended the research by showing the latest data (2021) on the number of cancers and examinations. Information on the occurrence and stage of esophageal, gastric, and colorectal cancers was collected from the same database.
View Article and Find Full Text PDFArticle Synopsis
- A novel nomogram was developed to assess the risk of lymph node metastasis (LNM) in patients with T1 colorectal cancer (CRC), incorporating various risk factors such as tumor budding and submucosal invasion depth.
- The study analyzed data from 4,673 T1 CRC patients across 27 institutions, identifying six key risk factors and demonstrating strong predictive ability with a concordance index around .790.
- This nomogram is the first of its kind to utilize real-world data and aims to enhance treatment strategies for patients diagnosed with T1 CRC based on comprehensive risk assessment.
Background: This is the first report from a multicenter prospective cohort study of colorectal neuroendocrine tumor (NET), the C-NET STUDY, conducted to assess the long-term outcomes of the enrolled patients. This report aimed to elucidate the clinicopathological features of the enrolled patients and lesions.
Methods: Colorectal NET patients aged 20-74 years were consecutively enrolled and followed up at 50 institutions.
Background: Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This study aimed to clarify the clinicopathological characteristics of SPS in Japan.
Methods: We investigated the clinicopathological characteristics of patients with SPS from the "Multicenter Study on Clinicopathological Characteristics of SPS (UMIN 000032138)" by the Colorectal Serrated Polyposis Syndrome (SPS) Study Group.
Based on the concept of the adenoma-carcinoma sequence, most colorectal cancers are considered to arise from conventional adenomas. However, recent studies suggested that a subset of colorectal cancers develop through the serrated neoplastic pathway. It has also been documented that serrated polyps can rapidly transform into invasive cancers even when they are small in size.
View Article and Find Full Text PDFBackground: Recent studies revealed that colorectal tumors are composed of genetically diverse subclones. We aimed to clarify whether the surface microstructures of colorectal tumors are associated with genetic intratumoral heterogeneity (ITH).
Methods: The surface microstructures (pit patterns) of colorectal tumors were observed using magnifying endoscopy, and biopsy specimens were obtained from respective areas when tumors exhibited multiple pit patterns.
Background: Colorectal serrated lesions (SLs) are important premalignant lesions whose clinical and biological features are not fully understood.
Aims: We aimed to establish accurate colonoscopic diagnosis and treatment of SLs through evaluation of associations among the morphological, pathological, and molecular characteristics of SLs.
Methods: A total of 388 premalignant and 18 malignant colorectal lesions were studied.
Colorectal sessile serrated adenoma/polyps (SSA/Ps) are well-known precursors of colorectal cancer (CRC) characterized by mutation and microsatellite instability. By contrast, the molecular characteristics of traditional serrated adenoma (TSAs) are not fully understood. We analyzed genome-wide DNA methylation in TSAs having both protruding and flat components.
View Article and Find Full Text PDFObjectives: Bowel cleansing is necessary before colonoscopy, but is a burden to patients because of the long cleansing time and large dose volume. A low-volume (2 L) hypertonic polyethylene glycol-ascorbic acid solution (PEG-Asc) has been introduced, but its possible dehydration effects have not been quantitatively studied. We compared the efficacy and safety including the dehydration risk between hypertonic PEG-Asc and isotonic PEG regimens.
View Article and Find Full Text PDFTo clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions' clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) and SSAs with dysplasia (n = 16).
View Article and Find Full Text PDFSerrated lesions, especially sessile serrated adenoma/polyps (SSA/P) are considered one of the most important precursors of colorectal cancers. However, it is still difficult to endoscopically differentiate SSA/P from hyperplastic polyps. In the present review, we mainly focus on the current status and future perspectives of endoscopic diagnosis of colorectal serrated lesions based on the results of a questionnaire survey and report from the Endoscopic Forum Japan (EFJ) 2015 held in Tokyo in August 2015.
View Article and Find Full Text PDFBackground And Aim: The plasma concentration of rabeprazole in patients treated for gastroesophageal reflux disease (GERD) has not been reported, although the concentration in healthy volunteers has been reported previously. Here, CYP2C19 genotype effects of rabeprazole on the area under the plasma concentration-time curve (AUC) and the pH elevation were studied in GERD patients.
Methods: Rabeprazole 10 mg/day was administrated for 8 weeks.