Publications by authors named "Hirdya N Verma"
Article Synopsis
- The study explores how Mycobacterium tuberculosis (Mtb) alters the endoplasmic reticulum (ER) in macrophages, revealing distinct ER structures for virulent (H37Rv) versus avirulent (H37Ra) strains.
- Using advanced proteomics and lipidomics, researchers found that these changes impact host-pathogen interactions, affecting protein and lipid composition in the ER.
- The findings suggest that H37Ra promotes apoptosis by manipulating calcium levels and lipid expression, while H37Rv inhibits apoptosis and disrupts cholesterol balance to ensure persistent infection.
To probe how the pathogen Mycobacterium tuberculosis controls host cellular death pathways, we compared mitochondrial responses in human macrophages infected either with the avirulent mycobacterial strain H37Ra, or its virulent counterpart H37Rv. Following H37Ra infection, induction of the apoptotic response was foreshadowed by the early suppression of stress-induced mitochondrial activity. In contrast, mitochondria in H37Rv-infected cells displayed robust activity with increased membrane potential and ATP synthesis.
View Article and Find Full Text PDFMolecular mechanism governing biological processes leading to dietary obesity and diabetes are largely unknown. Here we study the liver proteome differentially expressed in a long-term high-fat and high-sucrose diet (HFHSD)-induced obesity and diabetes mouse model. Changes in mouse liver proteins were identified using iTRAQ, offline 2D LC (SCX and RP) and MALDI-TOF/TOF MS.
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