Gabapentin, estrogen, and placebo for treating hot flushes: a randomized controlled trial.

Objective: To compare the efficacy of gabapentin, estrogen, and placebo in the treatment of hot flushes.

Methods: We performed a randomized, double-blind, placebo-controlled trial of 60 postmenopausal women to assess the efficacy of estrogen and gabapentin in the treatment of moderate-to-severe hot flushes. Participants were randomly assigned to receive either 0.