Publications by authors named "Hira Sajjad"
The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase protein family, and they represent an essential role in various diseases that occur because of abnormal activation, particularly in tumors development. Regulation of CRLs needs neddylation, a post-translational modification involving an enzymatic cascade that transfers small, ubiquitin-like NEDD8 protein to CRLs. Many previous studies have confirmed neddylation as an enticing target for anticancer drug discoveries, and few recent studies have also found a significant increase in advancement in protein neddylation, including preclinical and clinical target validation to discover the neddylation inhibitor compound.
View Article and Find Full Text PDFBackground: Haemonchosis is a fatal disease of small ruminants caused by the parasite Haemonchus contortus (H. contortus). The most common drugs used in the treatment of H.
View Article and Find Full Text PDFArticle Synopsis
- - Mastitis is a major health and economic issue in dairy animals, particularly affecting the udder health of Beetal goats in Pakistan, highlighting a need for more research on this disease.
- - A study screened 500 Beetal goats for mastitis, revealing a prevalence rate of 61.8% with significant cases of both subclinical and clinical mastitis, and identified common bacterial pathogens associated with the condition.
- - Antibiotic susceptibility tests showed that certain combinations (like amoxicillin+clavulanic acid) and specific antibiotics (like ceftiofur sodium) were effective against the identified bacterial strains, providing insights for treatment options.
Background: Strategies to minimize the risk of transmission and acquisition of COVID-19 infection in patients with ESKD receiving in-center hemodialysis have been rapidly implemented across the globe. Despite these interventions, confirmed COVID-19 infection rates have been high in the United Kingdom. Prevalence of asymptomatic disease in an adult hemodialysis population has not been reported.
View Article and Find Full Text PDFObjective: To determine the levels of serum thyroxine (T3, T4), triiodothyronine and thyrotropin in patients with acute myocardial infarction (AMI).
Methods: It was an observational prospective study and 60 patients (both males and females) of AMI, (diagnosed by ECG & cardiac enzymes.) were included.