Publications by authors named "Hira Mir"
Article Synopsis
- This study investigates the impact of pathological lymph node (LN) regression after neoadjuvant chemotherapy on survival rates in patients with esophageal adenocarcinoma, addressing a gap in existing research and defining LN response classifications.
- Conducted across five UK centers, the study analyzed 17,930 LNs from 763 patients, assigning scores based on the extent of residual tumor found in the nodes after treatment, with survival outcomes assessed using advanced statistical methods.
- Results showed that patients with complete or partial LN response had significantly lower mortality rates compared to those with poor or no LN response, highlighting LN regression as a vital prognostic factor that should be considered alongside traditional staging methods.
TERT (telomerase reverse transcriptase) is the catalytic component of telomerase. TERT shows little expression in normal somatic cells but is commonly re-expressed in cancers, facilitating immortalization. Recently-discovered promoter mutations create binding sites for ETS-family transcription factors to upregulate TERT.
View Article and Find Full Text PDFAs the pathogens soon develop resistance to the existing antibiotics, the demand for new and more effective anti-microbial agents is a continuous phenomenon. In this paper we are reporting synthesis and spectral data of eight Schiff bases of salicylaldehyde with different amines, and evaluation of their anti-microbial activities against different bacterial strains. The bases were synthesized by reflux method, and their structures were determined based FT-IR, (1)H-NMR, (13)C-NMR and Mass spectrometric data.
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