Publications by authors named "Hira Mazhar"
Article Synopsis
- Scientists found mutations in some important parts of a protein complex related to lung cancer.
- They created a new drug called YD23 that targets a specific part of this complex to help fight cancer cells.
- Testing showed that YD23 can slow down tumor growth in cells that have the mutations, which could help develop better treatments for certain lung cancers.
The interplay among signaling events for endothelial cell (EC) senescence, apoptosis, and activation and how these pathological conditions promote atherosclerosis in the area exposed to disturbed flow (d-flow) in concert remain unclear. The aim of this study was to determine whether telomeric repeat-binding factor 2-interacting protein (TERF2IP), a member of the shelterin complex at the telomere, can regulate EC senescence, apoptosis, and activation simultaneously, and if so, by what molecular mechanisms. We found that d-flow induced p90RSK and TERF2IP interaction in a p90RSK kinase activity-dependent manner.
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