Publications by authors named "Hiori Ikebe"
Article Synopsis
- Tyrosine kinase 2 (Tyk2) plays a key role in signaling related to IL-12 and IL-23, which are important in immune responses.
- In experiments using Tyk2 knockout (KO) mice, researchers found that these mice were resistant to experimental autoimmune encephalomyelitis (EAE), showing impaired Th1 cell differentiation and reduced Th1 cells, while Th17 cells were present but unresponsive to IL-23.
- The study suggests that Tyk2 is essential for pathogenic CD4 T cell responses in EAE, positioning it as a potential target for treating autoimmune diseases.
