Globunoids A-D, undescribed bichalconoid and biflavanoids with α-glucosidase and α-amylase inhibitory activities from Knema globularia stems.

A bichalconoid, globunoid A (1) and three biflavanones, globunoids B-D (2-4), previously undescribed, were isolated from the stems of Knema globularia, along with fourteen known analogues 5-18. The chemical structures of 1-4 were elucidated by the comprehensive spectroscopic analysis including UV, IR, HRESIMS, and NMR; the absolute configurations were determined based on their NOESY data, DP4+ statistical analysis, and ECD calculation. Up to now, compounds 2 and 3 represent the first 3,3″-linked biflavanone structures.

Identification and -glucosidase inhibitory activity evaluation of two new coumarins derived from J. R. Drumm.

Five coumarins were isolated from the heartwood of , which included two newly discovered compounds, namely 11-hydroxypopulene E () and mansorin D (), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The -glucosidase inhibitory activities of all isolated compounds were assessed in yeast.

External Focus Affects Drop Jump Performance: Focusing on Different Aims and Words of Instruction.

Attentional focus strategies eliciting external focus of attention effectively enhance drop jump (DJ) performance, however, their effects vary depending on the words used for the instructions. We aimed to examine the effects of different words on DJ performance using instructions eliciting external focus to minimize contact time (CT) or maximize jump height (JH). Twenty collegiate athletes performed DJs from a 30-cm platform after receiving one of the four instructions: two instructions (COND 1 and 2) about minimizing CT, and two instructions (COND 3 and 4) about maximizing JH.

α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei.

Nine undescribed sesquiterpenoids, along with ten known compounds, were isolated from the ethyl acetate extract of Mansonia gagei heartwood. Their structures were determined by spectroscopic data analysis (FTIR, 1D, 2D NMR, and HRESIMS), and their absolute configurations were established by ECD calculation. The isolated compounds were evaluated for their inhibitory effect against α-glucosidase from yeast.

Eumitrins I-K: three new xanthone dimers from the lichen Usnea baileyi.

In the continuing discovery and structure elucidation of natural xanthone dimers, which are still rarely reported in absolute configuration, three new xanthone dimers, eumitrins I-K (1-3) were isolated from the lichen Usnea baileyi, a rich source of natural xanthone dimers. Their structures were elucidated unambiguously by spectroscopic analyses, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance spectroscopy (1D and 2D NMR). The absolute configuration of all three compounds was established through DP4 probability and ECD calculation.

Age-related differences in kinetics during double- and single-leg jumps in boys.

Background: Plyometric training, such as single-leg jumps, may be one of the most effective ways to improve a child's jumping and sprinting ability. However, few studies on age-related changes in single-legged jumping ability seem to exist. Therefore, the aim of this study was to examine age-related changes in double- and single-leg jump performance.

A new neolignan and a new phenolic acid from the heartwood of J.R. Drumm.

One new neolignan () and one new phenolic compound (), together with four known compounds (- were isolated from the heartwood of . Their structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR and HRESIMS. The absolute configuration of was established based on the DP4+ protocol and by comparison of experimental and calculated ECD spectra.

Eumitrins F-H: three new xanthone dimers from the lichen and their biological activities.

The lichen is a fruticose lichen belonging to the . It is well known as a rich source of natural xanthone dimers and possesses various bioactivities. Nevertheless, the chemical investigation on this type of lichen is still rare as most of researches reported its components without structural elucidation.

Effect of Neutral, Internal, and External Focus on Drop Jump Performance: Is Drop Jump Performance Affected by Plyometric Training Experience?

Furuhashi, Y, Hioki, Y, Yoshimoto, S, and Hayashi, R. The effect of neutral, internal, and external focus on drop jump performance: is drop jump performance affected by plyometric training experience? J Strength Cond XX(X): 000-000, 2021-Providing an external focus of attention through verbal instructions can improve the drop jump (DJ) performance, which differs based on the skill level of athletes. The purpose of this study was to assess the effect of change of focus of attention on the performance of DJs in experienced and inexperienced athletes.

Garcinoic Acids and a Benzophenone Derivative from the Seeds of and Their Antibacterial Activities against Oral Bacterial Pathogenic Organisms.

In this study, three new garcinoic acid dimers, δ,δ-bigarcinoic acid (), δ,δ-bi--garcinoic acid (), and γ,δ-bi--garcinoic acid (), and a new benzophenone derivative, (8)-4-geranyl-3,5-dihydroxybenzophenone (), as well as seven known compounds (-) were isolated from the seeds of . The structures of the new compounds were elucidated using MALDI-TOF-MS and spectroscopic data, including 1D and 2D NMR and electronic circular dichroism spectra. All of the isolated compounds were evaluated for their antimicrobial activity against two oral pathogens, and .

Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins.

Lysine -pyrrolation, converting lysine residues to -pyrrole-l-lysine, is a recently discovered post-translational modification. This naturally occurring reaction confers electrochemical properties onto proteins that potentially produce an electrical mimic to DNA and result in specificity toward DNA-binding molecules such as anti-DNA autoantibodies. The discovery of this unique covalent protein modification provides a rationale for establishing the molecular mechanism and broad functional significance of the formation and regulation of -pyrrole-l-lysine-containing proteins.

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins.

Covalent modification of proteins exerts significant effects on their chemical properties and has important functional and regulatory consequences. We now report the identification and verification of an electrically-active form of modified proteins recognized by a group of small molecules commonly used to interact with DNA. This previously unreported property of proteins was initially discovered when the γ-ketoaldehydes were identified as a source of the proteins stained by the DNA intercalators.