Ratiometric Polymer Probe for Detection of Peroxynitrite and the Application for Live-Cell Imaging.

Peroxynitrite (ONOO) is one of the sources of oxidation stress involved in many biological signaling pathways. The role of ONOO being a double-edged sword in biological systems drives the development of effective detection tools. In this work, a boronate-based polymeric fluorescent probe PB-PVA was synthesized and the probe performance was evaluated.

Spiro[pyrrol-benzopyran]-based probe with high asymmetry for chiroptical sensing via circular dichroism.

This contribution describes an efficient approach to constructing chiral spiro[pyrrol-benzopyran] (SPP) scaffold with high asymmetry. By combining chiral SPP and the achiral sensing moiety phenothiazine, the target probe P showed unprecedented reaction-based chiroptical sensing towards hypochlorite with switching CD signals.