Practices and Strategies in Responsive Thematic Map Design: A Report from Design Workshops with Experts.

This paper discusses challenges and design strategies in responsive design for thematic maps in information visualization. Thematic maps pose a number of unique challenges for responsiveness, such as inflexible aspect ratios that do not easily adapt to varying screen dimensions, or densely clustered visual elements in urban areas becoming illegible at smaller scales. However, design guidance on how to best address these issues is currently lacking.

Constraint-Based Breakpoints for Responsive Visualization Design and Development.

This paper introduces constraint-based breakpoints, a technique for designing responsive visualizations for a wide variety of screen sizes and datasets. Breakpoints in responsive visualization define when different visualization designs are shown. Conventionally, breakpoints are static, pre-defined widths, and as such do not account for changes to the visualized dataset or visualization parameters.

Challenges and Opportunities in Data Visualization Education: A Call to Action.

This paper is a call to action for research and discussion on data visualization education. As visualization evolves and spreads through our professional and personal lives, we need to understand how to support and empower a broad and diverse community of learners in visualization. Data Visualization is a diverse and dynamic discipline that combines knowledge from different fields, is tailored to suit diverse audiences and contexts, and frequently incorporates tacit knowledge.

Understanding Barriers to Network Exploration with Visualization: A Report from the Trenches.

This article reports on an in-depth study that investigates barriers to network exploration with visualizations. Network visualization tools are becoming increasingly popular, but little is known about how analysts plan and engage in the visual exploration of network data-which exploration strategies they employ, and how they prepare their data, define questions, and decide on visual mappings. Our study involved a series of workshops, interaction logging, and observations from a 6-week network exploration course.

Design by Immersion: A Transdisciplinary Approach to Problem-Driven Visualizations.

While previous work exists on how to conduct and disseminate insights from problem-driven visualization projects and design studies, the literature does not address how to accomplish these goals in transdisciplinary teams in ways that advance all disciplines involved. In this paper we introduce and define a new methodological paradigm we call design by immersion, which provides an alternative perspective on problem-driven visualization work. Design by immersion embeds transdisciplinary experiences at the center of the visualization process by having visualization researchers participate in the work of the target domain (or domain experts participate in visualization research).

Construct-A-Vis: Exploring the Free-Form Visualization Processes of Children.

Building data analysis skills is part of modern elementary school curricula. Recent research has explored how to facilitate children's understanding of visual data representations through completion exercises which highlight links between concrete and abstract mappings. This approach scaffolds visualization activities by presenting a target visualization to children.

The Elicitation Interview Technique: Capturing People's Experiences of Data Representations.

Information visualization has become a popular tool to facilitate sense-making, discovery and communication in a large range of professional and casual contexts. However, evaluating visualizations is still a challenge. In particular, we lack techniques to help understand how visualizations are experienced by people.

Speculative Practices: Utilizing InfoVis to Explore Untapped Literary Collections.

In this paper we exemplify how information visualization supports speculative thinking, hypotheses testing, and preliminary interpretation processes as part of literary research. While InfoVis has become a buzz topic in the digital humanities, skepticism remains about how effectively it integrates into and expands on traditional humanities research approaches. From an InfoVis perspective, we lack case studies that show the specific design challenges that make literary studies and humanities research at large a unique application area for information visualization.

EMDialog: bringing information visualization into the museum.

Digital information displays are becoming more common in public spaces such as museums, galleries, and libraries. However, the public nature of these locations requires special considerations concerning the design of information visualization in terms of visual representations and interaction techniques. We discuss the potential for, and challenges of, information visualization in the museum context based on our practical experience with EMDialog, an interactive information presentation that was part of the Emily Carr exhibition at the Glenbow Museum in Calgary.

Stromal accumulation of chondroitin sulphate in mammary tumours of dogs.

To contribute to the investigation of the composition of the extracellular matrix in epithelial tumours, mammary gland tissues of dogs (including tumours, hyperplasias and normal tissue as well as metastatic lesions in lymph nodes and lung) were studied histochemically and immunohistochemically for distribution of sulphated glycosaminoglycans (s-GAGs). The formaline-fixed tissue was stained by alcian blue at pH 5.8, using the 'critical electrolyte concentration' to study the degree of sulphation of s-GAGs.

Necrotizing pneumonia in a cat caused by an orthopox virus.

A necrotizing pneumonia was observed in a domestic cat which had a clinical history of severe respiratory distress. Histology, immunohistology and electronmicroscopy revealed poxvirus as the causative agent. By the polymerase chain reaction and gene sequencing, an orthopox virus with 93% homology to cowpox virus was identified.

Lymphangiosarcomas in cats: a retrospective study of 12 cases.

Clinical, macroscopic, and histologic features of 12 lymphangiosarcomas in cats are described. Nine tumors were located in the subcutaneous tissue at the caudoventral abdominal wall (eight cats) or in the neck (one cat). The remaining three cats had lymphangiosarcomas around the cranial mesenteric artery (two cats) or precardial in the mediastinum (one cat).

[A case of necrotizing meningoencephalitis in a pug dog (pug dog encephalitis--PDE)].

A three-year-old female pug dog was euthanized because of recurrent seizures. Pathological examination revealed severe multifocal necrosis confined to the cerebrum. Histologically, areas of malacia of different stages, with prominent gitter cell infiltration were observed.

[Ascites as a result of peritoneal mesotheliomas in a horse].

An abdominal tumor was suspected after clinical evaluation in an eight-year-old, bay-coloured hannoveranian gelding. The diagnosis was based on the symptoms of ascites, on the results of the transcutaneous abdominal ultrasound examination and on the characteristic changes in the serum-electrophoresis. Postmortem a peritoneal mesothelioma was diagnosed.

[Leukoencephalomalacia in two horses--moldy corn poisoning in Germany?].

Moldy corn poisoning is a mycotoxicosis of Fusarium sp. causing a disease termed equine leukoencephalomalacia (ELEM). This article reviews the literature on ELEM and describes two cases with clinical signs and morphological findings comparable with fusariotoxicosis.

[Tumor cells on the inside and tumor cells on the outside. A contribution to the diagnosis and elucidation of the pathogenesis of mammary tumors in dogs].

This review discusses some recent experience with intra- and extracellular components of tumours as markers for tumour diagnosis. Intermediate filaments are cytoskeletal proteins of either epithelial or mesenchymal cells. Antibodies raised against human intermediate filament proteins cross-react with their canine counterparts.

Metabolism of ganglioside-amides in cultured human fibroblasts.

Metabolism of [3H]ganglioside derivatives GM3-amide and GM2-amide has been investigated in normal human skin fibroblasts. In a cell-free system the ganglioside analogues have been shown to enter biosynthetic pathways, their degradation, however, was curtailed at an early stage, as GM3-amide could not be hydrolysed by sialidase action. GM2-amide was susceptible to beta-hexosaminidase degradation yielding GM3-amide.

Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects.

Ganglioside GM2, 3H-labeled in the sphingoid base, was added to the culture medium of normal and GM2 gangliosidosis fibroblasts. Ganglioside was found to adsorb rapidly to the cell surface, most of it could however be removed by trypsination. The trypsin-resistant incorporation was about 10 nmol/mg cell protein, after 48 h.

[Adrenoleukodystrophy in a pair of siblings].

The diagnosis of adrenoleukodystrophy (ALD) in two brothers was confirmed by the analysis of long-chain fatty acids in cultured skin fibroblasts. The 23 year old brother was treated for Addison's disease at the age of 7 years. His first symptoms of ALD developed at the age of 22.

Diagnosis of infantile and juvenile forms of GM2 gangliosidosis variant 0. Residual activities toward natural and different synthetic substrates.

p-Nitrophenyl-6-sulfo-2-acetamido-2-deoxy-beta-D-glucopyranoside, which is known to be a specific substrate for human hexosaminidase A, has recently been used successfully for diagnosis of variants B and B1 of GM2-gangliosidosis (Fuchs et al. 1983; Kytzia et al. 1983; Li et al.

Release of sphingomyelin phosphodiesterase (acid sphingomyelinase) by ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes.

In cultured human fibroblasts and mouse L-cells the lysosomotropic agent, ammonium chloride, caused release of acid sphingomyelinase into the culture medium. The water-soluble enzymes were partially purified by sequential chromatography on ConA-Sepharose, octyl-Sepharose and Sepharose CL-4B. Mouse sphingomyelinase was purified up to 64-fold and human sphingomyelinase 134-fold from the culture medium.

[Collagen metabolism of fetal bone cultured in vitro].

Cultures of murine fetal bone explants were used as experimental model for the investigation of drug effects on mesenchymal metabolic processes, particularly the collagen metabolism. As parameters for growth or metabolic processes, resp., the increase in size, the DNA-, uronic acid- and hydroxyproline content of the explants were determined under various modifications of the culture conditions.