Publications by authors named "Hino S"

Poly-L-lysine (PLL) displays a high solubilizing ability for hydrophobic guest molecules, and when in complexes with guest molecules, it exhibits a high intracellular uptake. However, its high cytotoxicity, originating from its cationic character, significantly limits its applications in biological and medicinal chemistry. In this study, the amount of free PLL in an aqueous solution of a PLL-porphyrin complex was immensely reduced, resulting in considerably lower dark toxicity than that of the free PLL.

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Background: Early detection of cognitive decline, including mild cognitive impairment, is expected to provide a better prognosis. Several studies have suggested an association between periodontitis and mild cognitive impairment.

Objectives/design: To test the hypothesis that there is an association between severe periodontitis and mild cognitive impairment in community residents who participated in a dental health check-up program.

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Background: Intra-oesophageal acid stimulation increases masseter muscle activity. However, the infusion speeds used in previous studies are significantly slow, with minimal acid volume (30 mL over 30 min). Additionally, it is unclear how masseter muscle activity, symptoms of discomfort, stress levels and saliva quantity change over time.

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Metabolic reprogramming from oxidative respiration to glycolysis is generally considered to be advantageous for tumor initiation and progression. However, we found that breast cancer cells forced to perform glycolysis acquired a vulnerability to PARP inhibitors. Small-molecule inhibition of mitochondrial respiration-using glyceollin I, metformin, or phenformin-induced overproduction of the oncometabolite lactate, which acidified the extracellular milieu and repressed the expression of homologous recombination (HR)-associated DNA repair genes.

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Medication-related osteonecrosis of the jaw (MRONJ) caused by bisphosphonates (BPs) and denosumab (Dmab) is still a major oral adverse event caused by cancer treatment and may be under-recognized by private dental services. With the aim of reducing the prevalence of MRONJ, this study, which is a pilot study for a planned future large-scale survey, compared knowledge about MRONJ between dental hygienists (DHs) in private dental clinics and those in cancer center hospitals. We conducted a questionnaire-based survey regarding MRONJ between 1 November 2023 and 31 January 2024 on DHs at a cancer base hospital and a private clinic in Saitama, Japan.

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Biodegradable polymer-photosensitizer composites were developed, which is suppressed biodegradation due to bactericidal activity under light irradiation but proceeds under dark conditions. The composites exhibited antibacterial activity under light irradiation, which was attributed to the generation of singlet oxygen (O). Biodegradation was evaluated in seawater using the biochemical oxygen demand (BOD) method.

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  • The study assessed the effectiveness of boring biopsy in diagnosing subepithelial lesions (SEL) in the stomach and esophagus, involving 52 patients.
  • The diagnostic yield was found to be 50% for gastric SELs and 80% for esophageal SELs, with higher success rates for smaller lesions (less than 10mm).
  • Complications occurred in 10% of stomach biopsies, including two perforations and two cases of bleeding, while gastrointestinal stromal tumors were identified in 43% of gastric cases and all esophageal SELs were leiomyomas.
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The senescent microenvironment and aged cells per se contribute to tissue remodeling, chronic inflammation, and age-associated dysfunction. However, the metabolic and epigenomic bases of the senescence-associated secretory phenotype (SASP) remain largely unknown. Here, we show that ATP-citrate lyase (ACLY), a key enzyme in acetyl-coenzyme A (CoA) synthesis, is essential for the pro-inflammatory SASP, independent of persistent growth arrest in senescent cells.

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  • * In a sample of 67 PD patients previously diagnosed with dopamine transporter scintigraphy, TCS confirmed visibility of the midbrain in 64.1% of patients, while high-signal-intensity lesions were found in 35.8%.
  • * The findings suggest that patients with normal MIBG results may still have significant lesions, indicating that TCS could serve as a valuable diagnostic tool for identifying high-signal-intensity substantia nigra lesions in
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The alveoli, critical sites for gas exchange in the lungs, comprise alveolar epithelial cells and pulmonary capillary endothelial cells. Traditional experimental models rely on porous polyethylene terephthalate or polycarbonate membranes, which restrict direct cell-to-cell contact. To address this limitation, we developed AlveoMPU, a new foam-based mortar-like polyurethane-formed alveolar model that facilitates direct cell-cell interactions.

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  • * Data from 82 children revealed that most injuries occur in kids aged 2-7, primarily due to falls (89%) while using slides, swings, and iron bars.
  • * About half of the oral injuries were soft tissue injuries, with the rest involving teeth or jaw fractures, and fewer consultations for head injuries indicated they were usually minor.
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Nonocclusive mesenteric ischemia (NOMI) causes mesenteric ischemia and intestinal necrosis despite the absence of organic obstruction, such as thrombi and emboli in mesenteric blood vessels, and it has an extremely poor prognosis. We report a case of NOMI developed during bioradiotherapy (BRT) with cetuximab for cervical lymph node metastasis of tongue cancer. The patient was a 73-year-old man who underwent right radical neck dissection for neck lymph node metastasis after tongue cancer surgery.

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Since propionate exerts several physiological effects, maintenance of its normal colonic fermentation is essential. To investigate whether vitamin B (VB) is essential for normal propionate fermentation by colonic bacteria, via the succinate pathway, we examined if high-amylose cornstarch (HACS) feeding activated such a pathway, if high HACS feeding impaired propionate fermentation, and if oral VB supplementation normalized propionate fermentation. Male rats were given control, 20% HACS or 3% fucose diets (Expt.

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  • Spinal microglia and peripheral macrophages are important in neuropathic pain, with research indicating that male and female mice exhibit different pain sensitivities related to these cells.
  • In an experiment using pexidartinib to deplete myeloid cells in mice with nerve injury, male mice showed reduced pain sensitivity while female and gonadectomized male mice did not exhibit similar benefits.
  • The study highlights significant sex- and androgen-dependent differences in pain-related inflammatory responses in spinal microglia and dorsal root ganglia macrophages but not in sciatic nerve macrophages, emphasizing the need for further research on how these mechanisms vary across genders.
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Introduction The prognosis of oral squamous cell carcinoma (OSCC) is often poor despite standard treatments. Additionally, no useful prognostic markers are available. Therefore, we aimed to investigate the relationship between serum Interleukin-6 (IL-6) levels and prognosis and explore its local and systemic effects in patients with OSCC.

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Key Clinical Message: Foreign bodies penetrating from the oral cavity can damage surrounding tissues. This case is considered an extremely rare and fortunate instance in which a maxillary denture appeared to weaken the external force and change the direction of the scissors, preventing damage to vital organs.

Abstract: The patient was a 73-year-old man.

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  • The study aimed to assess the effectiveness and safety of MR-guided focused ultrasound (MRgFUS) treatment for patients with essential tremor, particularly focusing on those with a low skull density ratio (SDR).
  • Real-world data from 101 patients treated between July 2019 and March 2022 were analyzed, categorizing patients into four quartiles based on their mean SDR and evaluating treatment outcomes, parameters, and adverse events.
  • Results showed that MRgFUS significantly improved tremor severity across all SDR groups, but individuals with very low SDR experienced lower temperature and coagulation volume during treatment, along with more frequent adverse events, which mostly resolved by the 3-month follow-up.
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  • The Clinical Rating Scale for Tremor (CRST) is widely used but has limitations like ceiling effects and variability in test results when assessing essential tremor (ET).
  • This study tested videographic motion analysis as a new way to evaluate ET by recording patients performing tasks and analyzing the videos with software.
  • The findings showed that video analysis provided reliable measurements that correlated well with traditional CRST scores and was effective in tracking improvements after focused ultrasound treatment for tremor.
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Oral squamous cell carcinomas unusually show distant metastasis to the lung after primary treatment, which can be difficult to differentiate from primary squamous cell carcinoma of the lung. While the location and number of tumor nodules is helpful in diagnosing cases, differential diagnosis may be difficult even with histopathological examination. Therefore, we attempted to identify molecules that can facilitate accurate differential diagnosis.

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Surgical site infections (SSI) are associated with increased morbidity and mortality rates. This study aimed to investigate the ability of perioperative oral management (POM) to reduce the risk of SSI in abdominal surgery Real-world data collected from 16 university hospitals in Japan were reviewed. The medical records of consecutive 2782 patients (1750 men and 1032 women) who underwent abdominal surgery under general anesthesia at 16 university hospitals were retrospectively reviewed.

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If a foreign body is seen on chest or abdominal radiographs, accidental aspiration or ingestion of a dental-related foreign body may be suspected. This report describes a case in which vascular embolization coils seen on radiography were suspected to represent a swallowed dental prosthesis. A 72-year-old man with a history of endovascular embolization of portosystemic shunt was admitted for mandibular fracture.

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  • Laugier-Hunziker syndrome is a rare benign pigmentary disorder that causes pigmentation in the oral mucosa, nails, and skin, but is often overlooked by dental professionals.
  • A case study of an 84-year-old woman in an elderly care facility highlighted her oral mucosa discoloration, leading to a diagnosis of this syndrome.
  • Increasing awareness of conditions like Laugier-Hunziker syndrome is crucial for dental practice, particularly in settings with elderly patients.
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  • This study aimed to investigate the prevalence of oral mucosal pigmentation caused by various anticancer drugs during chemotherapy.
  • Over a three-year period, 388 patients were examined, and only 11 patients (2.8%) showed signs of pigmentation.
  • TS-1 was found to be the most likely drug to cause pigmentation, affecting 12.2% of its users, while other drugs like paclitaxel, gemcitabine, and cyclophosphamide also contributed to this side effect.
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Tetrakis(4-aminophenyl)porphyrin (1) and tetrakis(4-acetamidophenyl)porphyrin (2) were dissolved in water with the incorporation of a polysaccharide (λ-carrageenan (CGN)) as a water-solubilizing agent. Although the photodynamic activity of the CGN-2 complex was considerably lower than that of the CGN-1 complex, the selectivity index (SI; IC in a normal cell/IC in a cancer cell) of the CGN-2 complex was considerably higher than that of the CGN-1 complex. This is because the photodynamic activity of the CGN-2 complex was significantly affected by the intracellular uptakes by the normal and cancer cells.

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A 50-year-old woman experienced cardiopulmonary arrest. Although the arrest lasted for 4 min, she could not be withdrawn from the mechanical ventilator because of low tidal volume, despite being awake and alert after admission. The results of the anti-acetylcholine receptor antibody and repetitive nerve stimulation tests were negative, and the anti-muscle-specific kinase antibody levels revealed myasthenia gravis.

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