Publications by authors named "Hinke de Lau"

Objective: Preterm birth is a large-scale clinical problem involving over 10% of infants. Diagnostic means for timely risk assessment are lacking and the underlying physiological mechanisms unclear. To improve the evaluation of pregnancy before term, we introduce dedicated entropy measures derived from a single-channel electrohysterogram (EHG).

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Objective: Reducing perinatal morbidity and mortality is one of the major challenges in modern health care. Analysing the ST segment of the fetal electrocardiogram was thought to be the breakthrough in fetal monitoring during labour. However, its implementation in clinical practice yields many false alarms and ST monitoring is highly dependent on cardiotocogram assessment, limiting its value for the prediction of fetal distress during labour.

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Purpose: Timely diagnosing a uterine rupture is challenging. Based on the pathophysiology of complete uterine wall separation, changes in uterine activity are expected. The primary objective is to identify tocogram characteristics associated with uterine rupture during trial of labor after cesarean section.

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Objective: Observational cohort study which aimed to explore the potential of electrohysterogram (EHG) analysis for detecting a uterine rupture during trial of labor after cesarean. The EHG propagation characteristics surrounding the uterine scar of six patients with a previous cesarean section were compared to a control group of five patients without a scarred uterus.

Methods: The EHG was recorded during the first stage of labor using a high-resolution 64-channel electrode grid positioned on the maternal abdomen across the cesarean scar.

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Monitoring contractions during labour using the external tocodynamometer can be difficult or even impossible, and using the invasive intrauterine pressure catheter is associated with rare but serious complications. A new non-invasive technique is currently available: electrohysterography (EHG). This technique converts the electrical activity of the uterine muscle into a legible tocogram.

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Background: Traditional methods used for prediction of preterm delivery are subjective and inaccurate. The Electrohysterogram (EHG) and in particular the estimation of the EHG conduction velocity, is a relatively new promising method for detecting imminent preterm delivery. To date the analysis of the conduction velocity has relied on visual inspection of the signals.

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Background: Analysis of the electrohysterogram (EHG) is a promising diagnostic tool for preterm delivery. For the introduction in the clinical practice, analysis of the EHG should be reliable and automated to guarantee reproducibility.

Study Goal: Investigating the feasibility of automated analysis of the EHG conduction velocity (CV) for detecting imminent delivery.

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The electrohysterogram is a potential new tool for diagnosing preterm labor. Parameters from the electrohysterogram may be influenced by uterine movement. An observational study was performed quantifying uterine movement during labor as a step towards improving electrohysterogram analysis for predicting preterm labor.

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During pregnancy, analysis of the electrohysterogram (EHG), which measures the uterine electrical activity, can provide a fundamental contribution for the assessment of uterine contractions and the diagnosis of preterm labor. However, several aspects concerning uterine physiology and its link with EHG measurements are still unclear. As a consequence, the EHG is not yet part of the clinical practice.

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Objective: To compare group counselling to individual counselling with respect to the second trimester ultrasound.

Design: A prospective cohort study at two hospitals.

Method: At one hospital, 100 pregnant women were counselled on the risks and benefits of the second trimester ultrasound in groups of up to 15 patients.

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Purpose: To determine the risk of uterine rupture for women undergoing trial of labour (TOL) with both a prior caesarean section (CS) and a vaginal delivery.

Methods: A systematic literature search was performed using keywords for CS and uterine rupture. The results were critically appraised and the data from relevant and valid articles were extracted.

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