Publications by authors named "Hinayo Ichikawa"
Article Synopsis
- The study identified small molecules from the RIKEN NPDepo library that affect the production of 15-acetyldeoxynivalenol (15-ADON) in the fungus Fusarium graminearum, highlighting the strong stimulatory effect of the compound NPD12671.
- Dihydroartemisinin (DHA) emerged as an effective inhibitor of trichothecene production, showing over 50% inhibition at 1 μM by reducing the expression of the Tri6 gene, crucial for trichothecene biosynthesis.
- Experiments with a Tri6-overexpressing strain illustrated that while DHA did not inhibit trichothecene production in inducing conditions, it effectively suppressed mRNA accumulation of key biosynthesis genes
Trichothecene 3-O-acetyltransferase (TRI101) is an indispensable enzyme for the biosynthesis of trichothecenes, a group of mycotoxins produced by Fusarium graminearum. In this study, an inhibitor of TRI101 was identified by chemical array analysis using compounds from the RIKEN Natural Products Depository (NPDepo) library. Although the addition of the identified enzyme inhibitor to the fungal culture did not inhibit trichothecene production, it can serve as a candidate lead compound in the development of a mycotoxin inhibitor that inactivates fungal defense mechanisms.
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