No overall change in the rate of weight gain after switching to an integrase-inhibitor in virologically suppressed adults with HIV.

Objective: Excessive weight gain has been reported with integrase strand transfer inhibitors (INSTIs). We evaluated weight changes in virologically suppressed adults with HIV who switched from non-INSTI regimens to raltegravir (RAL)-containing or dolutegravir (DTG)-containing antiretroviral therapy.

Design: Retrospective single-centre cohort.