Publications by authors named "Hinako Narita"
Article Synopsis
- * Imaging tests revealed multiple brain and lung nodules, and blood tests indicated symptoms consistent with hemophagocytic syndrome.
- * A bone marrow examination confirmed the presence of Toxoplasma gondii, leading to treatment; however, the patient ultimately developed multiple organ failure and died shortly after admission.
Article Synopsis
- Most follicular lymphomas (FLs) are typically slow-progressing with good outcomes, but some patients face disease worsening within 24 months (POD24), leading to poorer results.
- This study aimed to identify predictive risk factors for POD24 and analyze the microenvironment characteristics in FL patients experiencing POD24.
- The research found that higher Ki-67 expression significantly correlates with POD24 events, and those patients also showed a decrease in certain immune cells, suggesting implications for targeted treatment approaches.
Article Synopsis
- This study compares two chemotherapy regimens used in patients undergoing umbilical cord blood transplantation: Flu/Mel/Bu2 (lower busulfan dose) and Flu/Mel/Bu4 (higher busulfan dose).
- Researchers analyzed data from 87 adult patients to see if there were differences in nonrelapse mortality, relapse rates, progression-free survival, and overall survival between the two regimens.
- The results showed no significant differences in outcomes, suggesting that the Flu/Mel/Bu2 regimen is a safe and effective option, particularly for older patients.
Article Synopsis
- Diffuse large B-cell lymphoma (DLBCL) shows varied clinical and genetic characteristics, but differences between primary extranodal and nodal DLBCL, especially involving double-expressor lymphoma (DEL), remain unclear.
- The study analyzed 61 primary extranodal and 128 nodal DLBCL cases, finding that nodal DLBCL had higher BCL2 expression, while DEL was linked to poor outcomes in extranodal cases.
- Results indicated that DEL significantly impacted progression-free and overall survival in primary extranodal DLBCL patients, establishing it as a crucial adverse prognostic factor.
Article Synopsis
- * Researchers examined 91 patients with blood cancers and found that those with certain FOXP3 genotypes (FOXP3-3279C/A or FOXP3-3279A/A) are at a significantly higher risk for severe chronic graft-versus-host disease (cGVHD).
- * The findings suggest that this genetic marker could help predict which patients are more likely to experience severe cGVHD after transplantation, aiding in better patient management.
Immune checkpoint inhibitor (ICI)-induced thrombocytopenias are rare immune-related adverse events (irAE), but ICI-related thrombotic thrombocytopenic purpura (TTP) is extremely rare. A 79-year-old woman with non-small cell lung cancer received maintenance therapy with the anti-human PD-L1 monoclonal antibody durvalumab. Four weeks after the last infusion, she developed overt TTP.
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