Pseudallescheria boydii (Scedosporium species) in 3 lung transplant recipients: computed tomography findings and literature review.

Objective: The objective of our study was to evaluate chest computed tomography (CT) findings in 3 lung transplant recipients infected with Pseudallescheria boydii complex or its asexual anamorph, Scedosporium apiospermum, 2 after double-lung transplant and 1 after single-lung transplantation. Awareness and early diagnosis of this rare but potentially lethal infection are important, as it is largely refractory to treatment with the antifungal agents of choice used for the more common Aspergillus species. Computed tomography investigation focused on the location, quality, and appearance of the various pulmonary lesions as well as the presence of cavitation, mediastinal lymphadenopathy, and pleural effusions.

Bronchoscopic approach to COPD.

Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition that has frequent morbidity and mortality, with associated costs of US $ 2.5 billion annually and nearly 14,000 deaths each year. In the most advanced stages it causes debilitating breathlessness which is not improved despite maximal medical therapy including smoking cessation, bronchodilators, steroids and supplemental oxygen.

Outcomes after lung transplantation in patients with chronic hepatitis C virus infection.

Background: Hepatitis C virus (HCV) infects 4 million people in the USA, with a prevalence of 1.4%. The seropositivity rate among potential lung transplant candidates is 1.

Scedosporium apiospermum (Pseudoallescheria boydii) infection in lung transplant recipients.

Background: Scedosporium apiospermum, the asexual counterpart of the teleomorph Pseudallescheria boydii, is increasingly recognized as an important opportunistic pathogen in transplant recipients. Infection is associated with a high rate of dissemination and poor outcome overall.

Methods: A retrospective analysis of The Cleveland Clinic lung transplant database identified 5 patients with S.