Microsecretory Adenocarcinoma: A Novel Salivary Gland Tumor Characterized by a Recurrent MEF2C-SS18 Fusion.

Salivary gland adenocarcinoma not otherwise specified (NOS) is a heterogenous group, likely containing distinct tumors not yet characterized. A growing number of low to intermediate-grade salivary carcinomas are now known to harbor tumor-specific gene fusions. On occasion, identifying a novel fusion allows for recognition of a new salivary tumor type, in addition to representing a potential diagnostic tool.

CD34-positive dendritic cells disappear from scars but are increased in pericicatricial tissue.

CD34-positive stromal cells (CD34SC) are distributed throughout the body, including the dermis. They are thought to play a role in maturation and proliferation of adjacent mesenchymal and epithelial stem cells and in immune responses. To investigate the role of such cells in wound healing after excision of cutaneous lesions, we examined the distribution and quantity of CD34SC in scars from the sites of removal of malignant skin tumors and from reconstructive surgery, as well as in samples of normal skin.

Immunoglobulin A pemphigus involving the perianal skin and oral mucosa: an unusual presentation.

Immunoglobulin A (IgA) pemphigus is a rare autoimmune blistering disease characterized by epidermal acantholysis and neutrophilic infiltrates, as well as intraepidermal IgA deposits. We report an unusual case of IgA pemphigus involving anal/ perianal skin and oral mucosa that demonstrated a successful response to dapsone treatment.

Solitary fibrous tumors of the skin: a clinicopathologic study of 10 cases and review of the literature.

Solitary fibrous tumor (SFT) is a relatively uncommon neoplasm that most commonly arises in the pleura. However, SFT is now known to affect various other anatomic sites as well, including rare examples in the skin, where the histologic features of this lesion may create diagnostic confusion with a variety of other spindle-cell tumors. In order to further the characterization of cutaneous SFT, all available cases of that entity were retrieved from the authors' institutional files.

E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters.

Our objective was to assess the loss of E-cadherin (EC) as a diagnostic marker or a predictor of prognosis. We stained 276 breast carcinomas with monoclonal antibodies to EC (invasive lobular carcinomas [ILC] and variants, 59; invasive ductal carcinoma and ductal special types [IDC], 204; tubulolobular carcinoma [TLC], 4; and invasive carcinoma [IC], uncertain whether lobular or ductal type, 9). The results were as follows: EC+IDCs, 99.

Primary cutaneous mucinous carcinoma: presence of myoepithelial cells as a clue to the cutaneous origin.

Background: Primary cutaneous mucinous carcinoma (PCMC) is a rare malignancy with probable apocrine differentiation. It is important to differentiate it from metastatic mucinous carcinoma (MMC), especially from the breast. The histologic and immunohistochemical features overlap between PCMC and breast mucinous carcinomas.

The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas.

Background: Distinguishing primary cutaneous adnexal neoplasms (PCANs) from metastatic carcinomas (MCs) can be difficult. We study the utility of p63, CK 5/6, CK 7, and 20 expression in PCAN vs. MC.