Cluster of Nontoxigenic Corynebacterium diphtheriae Infective Endocarditis and Rising Background C. diphtheriae Cases-Seattle, Washington, 2020-2023.

Background: Nontoxigenic Corynebacterium diphtheriae, often associated with wounds, can rarely cause infective endocarditis (IE). Five patients with C. diphtheriae IE were identified within 12 months at a Seattle-based hospital system.

SARS-CoV-2 seroprevalence rates of children seeking medical care in Louisiana during the state stay at home order.

Serologic testing of residual blood samples from 812 children from a hospital in New Orleans, LA, between March and May 2020, demonstrated a SARS-CoV-2 seroprevalence of 6.8% based on S and N protein IgG; Black and Hispanic children, and children living in zip codes with lower household incomes were over-represented.

Post-Ebola Syndrome Presents With Multiple Overlapping Symptom Clusters: Evidence From an Ongoing Cohort Study in Eastern Sierra Leone.

Background: Following the 2013-2016 West African Ebola outbreak, distinct, persistent health complaints were recognized in Ebola virus disease (EVD) survivors. Here we provide an in-depth characterization of post-Ebola syndrome >2.5 years after resolution of disease.

Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus.

Epstein-Barr virus (EBV) can be reactivated from latency into the lytic cycle by many stimuli believed to operate by different mechanisms. Cell lines containing EBV differ in their responses to inducing stimuli, yet all stimuli require de novo protein synthesis (44). A crucial step preliminary to identifying these proteins and determining when they are required is to measure the duration of stimulus and response time needed for activation of expression of EBV BRLF1 and BZLF1, the earliest viral indicators of reactivation.

Effects of attachment bereavement and pre-event conditions on subsequent depressive symptoms in older adults.

A sample of 1,411 older adults (age 55+) who had been interviewed both prior to and after bereavement were studied, allowing for pre-event controls. Those who had lost a parent, spouse, or child had the strongest depressive reactions, as predicted by an attachment-bonding hypothesis; however, material losses were also related to depression. Although bereavement/loss events were clearly related to subsequent depression even after pre-event depression, resources, and events were controlled, certain pre-event characteristics were predictive of the bereavement/loss events, including prior undesirable events, age, and urban/rural residency.

Effects of bereavement/loss and pre-event status on subsequent physical health in older adults.

Males and females aged fifty-five and older were interviewed before and after three types of bereavement/loss: attachment bereavement (child, spouse, parent), nonattachment bereavement (sibling, grandchild, close friend), and other losses (nonbereavements). Five measures of health were used. Before pre-event health was accounted for on self-report measures of health status and medical conditions, pre-event measures of environmental factors and impact measures of bereavement/loss events had significant but modest effects on post-event health.

Infant temperament and noncompliant behavior at four years: a longitudinal study.

Noncompliant behavior in early childhood (i.e., exaggerated, but age-appropriate negativism) has been inadequately studied.

The prevalence and correlates of anxiety symptoms in older adults.

An anxiety symptom scale was administered to a community sample of 713 males and 1338 females representative of persons aged 55 and older in Kentucky and quite similar to that of the US population in that age range. On the basis of a cutting point established previously, 17.1% of the males and 21.

Fatherless adolescents' feelings about their mothers--a pilot study.

Data from a study on feelings of Jerusalem high school students about their parents were used to explore fatherless adolescents' feelings about their mothers. Only eighteen such cases were found in this population and they were divided into two groups: twelve girls and six boys. The boys and the girls from two-parent families served as control groups.

Reliability and validity of five mental health scales in older persons.

Five scales were assessed as mental health measures for older persons: Affect Balance, The Center for Epidemiological Studies Depression Scale, General Well-Being, LSI-Z Life Satisfaction, and Trait-Anxiety Inventory. These scales were administered to a community sample of 279 older persons and a clinical sample of 109 older persons who were in psychiatric inpatient units. In both samples, the internal consistency reliabilities for the anxiety, depression, and well-being scales were moderately high to high, for the life satisfaction scale they were acceptable, but the reliabilities for the affect balance scale suggest some caution in its use.

Stability and melting kinetics of structural domains in the myosin rod.

The thermal stability and melting kinetics of the alpha-helical conformation within several regions of the rabbit myosin rod have been investigated. Cyanogen bromide cleavage of long myosin subfragment-2 produced one coiled-coil alpha-helical fragment corresponding to short subfragment-2 with molecular weight 90,000 (Mr = 45,000) and two fragments from the hinge region with molecular weights of 32,000 to 34,000 (Mr = 16,000 to 17,000) and 24,000 to 26,000 (Mr = 12,000 to 13,000). Optical rotation melting experiments and temperature-jump kinetic studies of long subfragment-2 and its cyanogen bromide fragments show that the hinge and the short subfragment-2 domains melt as quasi-independent co-operative units.

Prevalence of depression and its correlates in older adults.

Depression was studied in a community sample of 962 males and 1555 females aged 55 years and over living in Kentucky in 1981. The sample was representative of the population in Kentucky in that age group and quite similar to that US population. The Center for Epidemiologic Studies Depression Scale was used as a measure of depression, and 13.