Publications by authors named "Himawari Tachi"
Article Synopsis
- Sepsis significantly impacts drug distribution in the body, complicating the effectiveness and safety of antimicrobial treatments.
- In a study using rat models, the pharmacokinetics of various antibiotics were compared in normal versus septic conditions, revealing notable differences in how these drugs concentrate in organs.
- Specifically, vancomycin, arbekacin, and daptomycin showed increased kidney/plasma concentration ratios in septic rats, indicating potential kidney damage, while linezolid's distribution remained consistent across both groups, suggesting no need for dose adjustments in septic patients.
