Publications by authors named "Himan Mohamed-Mohamed"
(1) Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the patient suffers from an affection of both upper and lower motor neurons at the spinal and brainstem level, causing a progressive paralysis that leads to the patient's demise. Gender is also considered a predisposing risk factor for developing the disease. A brief review of the pathophysiological mechanisms of the disease is also described in this work.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. In parallel, Alzheimer's disease (AD) and vascular dementia (VaD) are the two leading causes of dementia in an increasingly long-living Western society. Numerous epidemiological studies support the role of T2D as a risk factor for the development of dementia.
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- ALS is a fatal neurodegenerative disease with no known cause, and metabolic changes like dyslipidemia are common in patients during its progression.
- The study aimed to examine the relationship between disease progression (measured by the ALS Functional Rating Scale or ALS-FRS) and early plasma lipid levels in ALS patients.
- A systematic review found no significant correlation between lipid levels and ALS-FRS scores at disease onset, suggesting more research is needed in this area.
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- Aging is a primary factor in the development of Alzheimer's disease, but chronic conditions like obesity and high cholesterol can worsen dementia progression.
- Research indicates a link between low-density lipoprotein receptor (LDLR) and amyloid-beta (Aβ) in Alzheimer's pathology, with LDLR influencing lipid transport and inflammatory responses.
- In experiments with mice fed a high-saturated fat diet, researchers observed obesity and cognitive decline, suggesting that metabolic syndromes can significantly impact brain health and cognitive function in relation to Alzheimer's.
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- Parkinson's disease (PD) is a neurodegenerative disorder caused by the death of dopamine-producing neurons, characterized by the formation of toxic Lewy bodies from alpha-synuclein proteins.
- Current research is focused on novel treatments targeting alpha-synuclein through various methods, like reducing its accumulation and using immunotherapy, though no definitive cure exists yet.
- A comprehensive treatment approach combining pharmacological and non-pharmacological strategies is essential for managing symptoms and improving the quality of life for individuals with PD.
Life expectancy has been boosted in recent decades at expenses of increasing the age-associated diseases. Dementia, for its incidence, stands out among the pathologies associated with aging. The exacerbated cognitive deterioration disables people from carrying out their daily lives autonomously and this incidence increases exponentially after 65 years of age.
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