Publications by authors named "Himakshi K Patel"
mRNA vaccines have been established as a safe and effective modality, thanks in large part to the expedited development and approval of COVID-19 vaccines. In addition to the active, full-length mRNA transcript, mRNA fragment species can be present as a byproduct of the cell-free transcription manufacturing process or due to mRNA hydrolysis. In the current study, mRNA fragment species from BNT162b2 mRNA were isolated and characterized.
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- PEGylation of therapeutic proteins can extend their effectiveness in the body, and this study focuses on three types of TNF Nanobody-PEG conjugates: linear, branched, and their effects on pharmacokinetics and biodistribution.
- The branched PEG conjugates showed a better pharmacokinetic (PK) profile than the linear ones, though all had similar potency in testing.
- Biophysical analysis revealed that the linear PEG conjugate was more extended and exposed, which may contribute to its lower effectiveness in the body compared to branched ones, suggesting that further research is necessary to confirm these findings.