Genome sequences of bacteriophages that infect Typhi from Bangladesh.

This report presents near-complete genome sequences of 14 bacteriophages that infect Typhi, identified through environmental surveillance in Bangladesh between August 2021 and June 2022. The bacteriophages, belonging to the genera , , and , exhibit high degrees of sequence similarity and conserved genetic features with previously reported Typhi bacteriophages.

Old tools, new applications: Use of environmental bacteriophages for typhoid surveillance and evaluating vaccine impact.

Typhoid-conjugate vaccines (TCVs) provide an opportunity to reduce the burden of typhoid fever, caused by Salmonella Typhi, in endemic areas. As policymakers design vaccination strategies, accurate and high-resolution data on disease burden is crucial. However, traditional blood culture-based surveillance is resource-extensive, prohibiting its large-scale and sustainable implementation.

In-silico approach of identifying novel therapeutic targets against Yersinia pestis using pan and subtractive genomic analysis.

The magnitude of human affliction brought about by bacterial infections has been on the rise since the mid-5th century. Yersinia pestis is one such notable, gram-negative bacterium that inflicted havoc around the globe three times throughout different millenniums by causing deadly plagues. Despite the unremitting efforts by scientists, different strains of Yersinia pestis are still affecting the populations in various parts of the world by growing resistant to existing antimicrobial agents owing to their overuse.