J Thromb Thrombolysis
February 2009
Background: This study investigated the effect of either oral or transdermal hormone replacement therapy (HRT) on haemostatic, fibrinolytic and lipid profiles in a group of Brazilian women 3 months after beginning treatment by comparing these results with those obtained immediately before HRT.
Methods: Plasma levels of TAT, DDi, F1+2, PC, PS, AT, PAI-1 and serum lipids were determined in blood samples collected from 24 women undergoing oral HRT and from 11 women undergoing transdermal HRT.
Results: Significant increases in DDi and F1+2 plasma levels were observed after 3 months of oral HRT, while PS levels decreased.