Publications by authors named "Hilton A"

Southern shagbark hickory (Carya carolinae-septentrionalis) is one of several deciduous trees in the family Juglandaceae and genus Carya that are native to North America. Southern shagbark hickory has a restricted distribution to the Southeast U.S.

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Purpose: Research in adults suggests that altitude impacts the restorative properties of sleep and increases risk for mental health concerns. The aim of this study was to extend this research to an adolescent sample to examine how living at altitude may be associated with greater sleep need and mental health symptoms during a period of the life-span when risk for insufficient sleep and mental health difficulties is high.

Methods: Data were collected from 105 adolescents aged 10-17 years residing at moderate-high altitudes.

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  • Acute leukaemias (AL) are severe blood cancers that can be treated with intensive chemotherapy, but this also increases the risk of serious infections, particularly invasive fungal infections (IFIs), due to low white blood cell counts (neutropenia).
  • Current guidelines suggest using antifungal agents as a preventive measure in high-risk patients, but there's a significant issue of overprescribing these medications. Biomarkers like galactomannan and β-D-glucan could improve the diagnosis of IFIs when used together rather than separately.
  • The BioDriveAFS study is a large clinical trial involving 404 participants that will compare a biomarker-based antifungal management strategy to traditional antifungal prophyl
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Pelvic organ prolapse (POP), a downward descent of the vagina and/or uterus through the vaginal canal, is a prevalent condition affecting up to 40% of women. Several risk factors of POP have been identified, including childbirth, connective tissue defects, and chronic intra-abdominal pressure; however, the underlying etiologies of POP development are not fully understood, leading to a high burden on patients and the healthcare systems. The uterosacral ligaments are key support structures of the uterus and upper vagina.

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Background: The principle of epistemic justice (EJ) recognises the need for a person's voice to be both heard (testimonial) and understood (hermeneutic) in the generation of meaning. Funding bodies now require all research to have embedded patient and public involvement (PPI) - an active partnership between patients, carers, and the public with researchers, which influences and shapes research.

Aim: Current PPI initiatives potentially enable testimonial justice - ensuring voices are heard.

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Background: Sleep disturbance is a prevalent condition among people living with dementia (PLwD) or mild cognitive impairment (MCI). Its assessment and management within primary care is complex because of the comorbidities, older age, and cognitive impairment typical of this patient group.

Aim: To explore how primary care clinicians assess, understand, and manage sleep disturbance for PLwD or MCI; if and why such initiatives work; and how people and their carers experience sleep disturbance and its treatment.

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  • Patient and public involvement and engagement (PPIE) in healthcare research ensures that research is conducted "with" or "by" the public, emphasizing active participation in shaping research directions rather than being passive subjects.
  • The TIMES study, focused on improving sleep management for individuals with dementia, has effectively integrated PPIE by valuing the voices of participants and collaborating with various community organizations.
  • The editorial highlights the importance of inclusivity and shares practical experiences and tips for researchers, drawing on six key UK standards for public involvement and featuring a diverse advisory forum incorporating various community perspectives.
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Objectives: The purpose of this study is to examine adolescent attitudes about the importance of sleep and how they relate to adolescent sleep behaviors and parent sleep attitudes.

Methods: Participants included families with adolescents aged 10-17years and a parent (N = 170 dyads) who completed a virtual assessment. Adolescents reported on their sleep impairment and sleep hygiene behaviors, and all participants completed a newly developed scale to assess attitudes toward the importance of prioritizing sleep over other activities/responsibilities.

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Assessments of the severity of scab (), an economically significant disease of pecan, are critical for determining pecan cultivar susceptibility, disease epidemiology, and integrated disease management approaches. We developed a standard area diagram (SAD) set to aid in assessments of pecan leaflet scab. Leaflets with scab lesions were harvested and scanned using a flatbed scanner at 600 dpi, and Fiji (ImageJ) was used to determine the actual percent disease severity.

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On average, people with dementia live with 4.6 additional health conditions. Additionally, two thirds of carers of people with dementia are spouses, and are also likely to live with multimorbidity, given that older age is strongly associated with an increase in health conditions.

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Water supplies for household use and irrigated agriculture rely on groundwater wells. When wells are drilled into a highly pressurized aquifer, groundwater may flow up the well and onto the land surface without pumping. These flowing artesian wells were common in the early 1900s in the United States before intensive groundwater withdrawals began, but their present-day prevalence remains unknown.

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Purpose: In response to the COVID-19 pandemic, virtual consultations were introduced rapidly across cancer services. This created a particular set of challenges for systemic anticancer therapy services, where patients have frequent, regular appointments to support decision-making regarding treatment. This study explores the experiences of staff who provide these consultations to understand the implications for patients, staff, and services.

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Aim: The aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough.

Methods: A systematic search was conducted to identify all studies that used qualitative methodology to report on the experiences of adults living with chronic cough. A thematic synthesis of the first-hand narratives was undertaken.

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Purpose: The Centers for Disease Control and Prevention's National Comprehensive Cancer Control Program (NCCCP) requires that states develop comprehensive cancer control (CCC) plans and recommends that disparities related to rural residence are addressed in these plans. The objective of this study was to explore rural partner engagement and describe effective strategies for incorporating a rural focus in CCC plans.

Methods: States were selected for inclusion using stratified sampling based on state rurality and region.

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  • The study evaluated the impact of socioeconomic status (SES) on outcomes for patients receiving extracorporeal life support (ECLS), using the Distressed Communities Index (DCI) and Area Deprivation Index (ADI) scores.
  • Findings showed no significant differences in mortality during hospitalization or long-term survival based on SES, with both indices yielding similar results.
  • Overall, the research concluded that SES, as measured by DCI and ADI scores, does not significantly affect survival rates after ECLS at the medical center studied.
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Purpose: To identify physical activity (PA) barriers and facilitators among Black and African American (Black/AA) cancer survivors that should be considered in future PA intervention development for this population.

Methods: A community advisory board (CAB) of Black/AA cancer survivors and patient advocates guided in-depth qualitative interviews (n = 19) that were completed via telephone using a semi-structured interview guide. Interviews were transcribed verbatim, and data were analyzed using directed content analysis to detail a report of PA barriers and facilitators during and after cancer treatment.

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  • * A study on rats revealed that zapnometinib has low absorption in the gastrointestinal tract, with over 90% excreted in feces within 48 hours, and is quickly distributed throughout the body, mainly accumulating in circulatory and visceral tissues.
  • * The drug's maximum concentration in the plasma and tissues occurs 2-8 hours after dosing, with minimal brain penetration and almost complete elimination from most tissues after 168 hours; the primary metabolic clearance involves oxidative reactions and glucuronidation.
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  • The ageing population is leading to an increase in individuals living with dementia and mild cognitive impairment (MCI), resulting in a significant prevalence of sleep disturbances, yet there's no standardized management in UK primary care.
  • This realist review aims to explore definitions, assessments, diagnoses, and management of sleep disturbances among people with dementia or MCI by engaging a group of stakeholders, including patients and healthcare professionals.
  • The findings will contribute to developing a tailored sleep management tool and will follow ethical guidelines and reporting standards to ensure clarity and transparency in the results.*
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  • Sleep loss negatively affects social motivation and positive emotions in healthy young adults, with participants who had restricted sleep showing less desire to connect with others.
  • In an experiment, those who slept only 4 hours reported reduced feelings of gratitude and connectedness after reflecting on positive social experiences compared to those who slept for 8 hours.
  • The study highlights a gap in research on how sleep influences social connections, suggesting that partial sleep restriction can diminish the quality of social interactions and emotional well-being.
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Temperament in early childhood is a good predictor of later personality, behavior, and risk of psychopathology. Variation in temperament can be explained by environmental and biological factors. One biological mechanism of interest is the gut microbiome (GM), which has been associated with mental and physical health.

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Background: Older people and people with dementia experience a high prevalence of multiple health conditions. The terms 'comorbidity' and 'multimorbidity' are often used interchangeably to describe this, however there are key conceptual differences between these terms and their definitions. This has led to issues in the validity and comparability of research findings, potentially inappropriate intervention development and differences in quality of health care.

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To enhance patient-centred care of people with hip pain, we need a comprehensive understanding of peoples' beliefs about their hip pain. This systematic review explored the beliefs and expectations of middle-aged and older adults about chronic hip pain and its care across different healthcare settings and contexts. This review was a synthesis of qualitative studies using a framework synthesis approach.

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