Publications by authors named "Hilman Nurmahdi"
Article Synopsis
- The Notch receptor is activated by ligands from the Delta/Serrate/Lag-2 family, but the structure of its signaling complex is not fully understood.
- This study focuses on the Notch-1 EGF 20-27 region, using advanced techniques like crystallography and NMR, revealing it has a rigid yet flexible structure influenced by calcium ions.
- Findings indicate that variations in the Notch-1 protein affect its activation by ligands, highlighting the importance of calcium in maintaining structural integrity and the role of different interactions in Drosophila mutations.
Notch signaling plays various roles in cell-fate specification through direct cell-cell interactions. Notch receptors are evolutionarily conserved transmembrane proteins with multiple epidermal growth factor (EGF)-like repeats. Notch has 36 EGF-like repeats, and while some play a role in Notch signaling, the specific functions of most remain unclear.
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