Role of sequential biopsy study in the evaluation of renal transplant.

Renal biopsy is indicated in all cases of renal transplants showing renal dysfunction. This not only helps in the diagnosis but also in the institution of proper management. Study of sequential biopsies is essential for establishing the cause of renal dysfunction, evaluation of the effect of treatment and the progress of the disease.

Rhinoscleroma: a clinicopathological study from the Gulf region.

Introduction: Rhinoscleroma is a chronic progressive inflammatory disease of the upper respiratory tract. We report a clinicopathological series from the Gulf region.

Methods: The clinical and pathological features of patients diagnosed with rhinoscleroma at three main hospitals in Saudi Arabia and Bahrain over a 20-year period are presented.

Pathogenesis of balls in mature ovarian cystic teratoma. Report of 3 cases and review of literature.

Ovarian cystic teratomas with intracystic balls are rare, and only 11 cases have been reported since 1946. We present 2 new cases and review the literature for the clinical presentation and morphological appearances of the cysts and balls. We also present our histology findings on a third case reported in the international literature.

Oesophageal cancer in Bahrain.

ABSTRACT Data from all 148 cases of oesophageal cancer in Bahrain during 1952-99 were analysed according to patient sex and age and site and histological pattern of tumour, and compared with other Gulf countries. In Bahrain, oesophageal cancer accounted for 2.6% of malignant neoplasms.

Formal total synthesis of (-)-apicularen A via transannular conjugate addition.

The formal total synthesis of the myxobacteria metabolite (-)-apicularen A (1) is described. The key step involved a novel acid-mediated transannular conjugate addition of the C13 hydroxyl into the alpha,beta-unsaturated ketone in either of the macrolactones 5a or 5b to provide the same trans-pyranone 4. Conversion of 4 into the known apicularen intermediate diol 3 completed the formal synthesis.

Spectrum of malignant lymphomas in Bahrain. Leitmotif of a regional pattern.

Objective: To determine the clinicopathologic features of malignant lymphomas in Bahraini patients.

Methods: A retrospective hospital-based study was conducted. All new cases of malignant lymphoma diagnosed during the period January 1996 to December 2001 at the Salmaniya Medical Complex in Bahrain were included in the study.

The pathological expressions of Brunners gland hyperplasia into adenoma and hamartoma.

The terms Brunners gland adenoma and hamartoma are 2 pathological expressions of hyperplasia of these glands. We report 3 patients and review the recent literature to support our hypothesis of common pathology. Awareness of the existence and character of Brunners gland lesions will increase the possibility of their accurate diagnosis.

Primary dissecting hepatic artery aneurysm in pregnancy.

A 32-year-old 32 weeks pregnant primigravida presented with acute abdomen and died 13 h later. She was normotensive during her antenatal period and on admission. At postmortem, a primary dissecting aneurysm of the main hepatic artery extending into its intrahepatic right branch was found.

Hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in hospital births in Bahrain.

In view of the high prevalence of clinical cases of sickle cell anemia, hemoglobin-H-disease and glucose-6-phosphate dehydrogenase deficiency in the archipelago of the State of Bahrain, a cord blood screening study was undertaken over a 15 month period (October 1984 to December 1985) to determine the gene frequency of these diseases. All the state hospitals participated in this study and a total of 10,327 cord blood samples obtained from babies born to Bahraini parents were analyzed. These presented over 80% of all neonates born in the country during the study period.

Secondary chordoma of the mandible.

The first case of primary sacrococcygeal chordoma metastasising to the mandible and presenting with obstructed labour is described. The pathological features of this tumour, its clinical presentation and management are discussed.

The function of the gallbladder as a lesser biliary circulation.

The function of the gallbladder is questioned in a hypothesis postulating that all bile which enters this reservoir is totally absorbed to the liver and none of it flows back to the cystic duct and duodenum. Cholecystokinesis is believed to increase and maintain a gradient of intravesical pressure which increases the filtration pressure necessary for the absorption of bile to the liver. The absorption is through the tributaries of the cystic veins, the ducts of Luschka and Rokitansky-Aschoff sinuses.

Rhinosporidiosis in Bahrain, Arabian Gulf.

Rhinosporidiosis occurred in Bahrain only in Indian expatriate workers who had the disease in India before coming to Bahrain. The pathological and clinical aspects of the disease as well as its possible health hazard in Bahrain are discussed.

The short term effects of a supra-lethal dose of irradiation and changes in the environmental temperature on the growth of tail bones of the mouse.

The growth and histological features of the tail vertebrae of young mice (31 day old) were observed for 48 h after transference from a cold (8 degrees) to a hot (33 degrees) environment. Some mice received a massive (5000 rad) dose of X-ray to the tail. Less than 2 h after housing the animals in the heat there was a period of very rapid growth lasting 12 h after which time growth slowed but was still much greater than the animals in the cold.

The effects of changes in the environmental temperature on the growth of bone in the mouse. Radiological and morphological study.

Groups of 25-day-old mice were kept at 33 degrees, 21 degrees and 8 degrees for up to 195 days. Measurements and observations on length, width, gross and microscopic structure using radiological and histological techniques were made on central and peripheral bones. Tail bones of animals kept at 33 degrees grew longer and faster than those in the cold but also closed their epiphyses earlier.

The effects of changes in the environmental temperature on the growth of tail bones in the mouse.

The tails of baby mice grow rapidly and independently of environmental temperature because they are kept warm by their mothers. After weaning, at approximately 3 weeks of age, tail growth is strictly related to environmental temperatures. During the first 2 weeks after weaning growth rates of 1.