Dermal penetration of 2-phenoxyethanol in humans: in vivo metabolism and toxicokinetics.

2-Phenoxyethanol (PhE) is an amphiphilic organic compound frequently used as a broad-spectrum preservative in cosmetic products and other consumer goods. PhE is also used as a biocidal component in occupational settings. A previous volunteer study by our working group following oral exposure to PhE showed that PhE is almost completely taken up into the human body followed by an extensive metabolization and fast urinary elimination.

Toxicokinetics of benzotriazole UV stabilizer UV-P in humans after single oral administration.

UV-P (2-(2H-Benzotriazol-2-yl)-p-cresol) is used as an ultraviolet (UV) light absorber in coating products, paints, adhesives, and sealants. Due to its widespread industrial and consumer uses, human exposure to UV-P is conceivable. In the study presented herein, initial data on its human in vivo metabolism were obtained for three study participants after single oral administration of 0.

Fluorescence lifetime imaging unravels the pathway of glioma cell death upon hypericin-induced photodynamic therapy.

Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative so-called guerilla cells is photodynamic therapy (PDT) using organic photosensitizers that can pass the disrupted blood-brain-barrier and selectively accumulate in tumor tissue.

The LTAR Grazing Land Common Experiment at Platte River High Plains Aquifer.

The Long-Term Agroecosystem Research (LTAR) network of the United States Department of Agriculture (USDA) consists presently of 18 sites within the contiguous United States that are managed by the Agricultural Research Service (ARS) and its partners. The LTAR network focuses on developing national strategies for more efficient, resilient, and profitable agricultural production systems, improved environmental quality, and enhanced rural prosperity. The Platte River High Plains Aquifer (PRHPA) LTAR site is managed jointly by the University of Nebraska-Lincoln (UNL) and USDA-ARS and is one of the LTAR sites that conduct research on both integrated cropping and grazing systems.

New metabolites of 2-ethylhexyl salicylate in human urine after simulated real-life dermal sunscreen application.

2-Ethylhexyl salicylate (EHS) is an organic UV filter which is used in sunscreen and other personal care products. The dermal uptake of EHS was studied in several dermal-exposure experiments. This paper aims to coherently assess urine samples after dermal exposure for the biomarkers EHS, 5OH-EHS, 5oxo-EHS, and 5cx-EPS as well as further biomarkers of interest, specifically 4OH-EHS, 4oxo-EHS, 2OH-EHS, and 6OH-EHS, for the first time.

A simple 230 MHz photodetector based on exfoliated WSe multilayers.

We demonstrate 230 MHz photodetection and a switching energy of merely 27 fJ using WSe multilayers and a very simple device architecture. This improvement over previous, slower WSe devices is enabled by systematically reducing the RC constant of devices through decreasing the photoresistance and capacitance. In contrast to MoS, reducing the WSe thickness toward a monolayer only weakly decreases the response time, highlighting that ultrafast photodetection is also possible with atomically thin WSe.

Comprehensive assessment of the UV-filter 2-ethylhexyl salicylate and its phase I/II metabolites in urine by extended enzymatic hydrolysis and on-line SPE LC-MS/MS.

2-ethylhexyl salicylate (EHS) is used as a UV filter in personal-care products, such as sunscreen, to prevent skin damage through UV radiation. The application of EHS-containing products leads to systemic EHS absorption, metabolization and excretion. To measure EHS and its corresponding metabolite levels in urine, a comprehensive analytical procedure based on an extended enzymatic hydrolysis, on-line-SPE, and UPLC-MS/MS was developed.

Colloidal 2D MoWS nanosheets: an atomic- to ensemble-level spectroscopic study.

Composition dependent tuning of electronic and optical properties in semiconducting two-dimensional (2D) transition metal dichalcogenide (TMDC) alloys is promising for tailoring the materials for optoelectronics. Here, we report a solution-based synthesis suitable to obtain predominantly monolayered 2D semiconducting MoWS nanosheets (NSs) with controlled composition as substrate-free colloidal inks. Atomic-level structural analysis by high-angle annular dark-field (HAADF) scanning transmission electron microscopy (STEM) coupled with energy dispersive X-ray spectroscopy (EDXS) depicts the distribution of individual atoms within the MoWS NSs and reveals the tendency for domain formation, especially at low molar tungsten fractions.

[Economic Relevance of Preventable Prohibitions of Employment in Bavarian Schools].

Introduction: According to the Maternity Protection Act, an occupational risk of infection (e. g. in childcare) - combined with individual immunity gaps - can result in an irresponsible risk for pregnant women in the workplace.

Elevated aluminum excretion in patients by long-term subcutaneous immunotherapy - A cross-sectional case-control study.

Background: Aluminum (Al) adjuvants have been used in vaccines and subcutaneous immunotherapy (SCIT) for decades. Despite indisputable neurotoxic properties of Al, there is no clear evidence of a causal relationship between their use and any neurotoxic side effects. However, recent rat studies have shown an accumulation of Al from adjuvants in tissues, especially in bones.

Impact of the COVID-19 outbreak on blood supply in two large university hospitals.

Objective: This study aimed to examine the relationship between the decrease in elective procedures and the need for blood donation during the novel coronavirus disease (COVID-19) pandemic at university hospitals.

Background: The COVID-19 pandemic has immensely impacted transfusion medicine. By cancelling elective surgery, the German government hoped to increase the available resources for patients infected with COVID-19, especially in intensive care units, and prevent the shortage of blood products.

On the horns of a dilemma: choosing total intravenous anaesthesia or volatile anaesthesia for cancer surgery, an enduring controversy.

Two methods for administering general anaesthesia are widely used: propofol-based total intravenous anaesthesia (propofol-TIVA) and inhalation volatile agent-based anaesthesia. Both modalities, which have been standards of care for several decades, boast a robust safety profile. Nevertheless, the potential differential effects of these anaesthetic techniques on immediate, intermediate, and extended postoperative outcomes remain a subject of inquiry.

Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions.

Bipolar disorder (BD) is a disabling disorder with heterogeneous symptom profiles and trajectories. Like many other neuropsychiatric disorders, clinical decision making related to diagnoses and choice of treatment is based on clinical assessments alone, and risk prediction for treatment success or resistance at an individual level remains sparse. An enormous effort to add biological markers to this risk prediction is ongoing.

Towards the definition of metrics for the assessment of operational design domains.

The Operational Design Domain (ODD) of an automated driving function defines on which roads and under which environmental conditions the function is safe to operate. It plays an important role in definition, safety analysis and validation of automated driving. In many cases, users want to determine metrics about ODDs, or about ODDs in combination with other work products, like collections of validation scenarios.

Rapid online plant leaf area change detection with high-throughput plant image data.

High-throughput plant phenotyping (HTPP) has become an emerging technique to study plant traits due to its fast, labor-saving, accurate and non-destructive nature. It has wide applications in plant breeding and crop management. However, the resulting massive image data has raised a challenge associated with efficient plant traits prediction and anomaly detection.

Exploiting Big Data for Experiment Reporting: The Hi-Drive Collaborative Research Project Case.

As timely information about a project's state is key for management, we developed a data toolchain to support the monitoring of a project's progress. By extending the Measurify framework, which is dedicated to efficiently building measurement-rich applications on MongoDB, we were able to make the process of setting up the reporting tool just a matter of editing a couple of .json configuration files that specify the names and data format of the project's progress/performance indicators.

Effect of an aluminum foil-processed diet on internal human aluminum burden.

Background And Purpose: Aluminum can be released into food by aluminum-containing food-contact materials (Al-FCM) during preparation or storage. There is considerable concern that extra aluminum intake may have negative effects on public health, especially with regard to its high background exposure and neurotoxic properties of aluminum in high exposures. Human in-vivo data on the additional aluminum load from Al-FCM, however, are lacking.

Pig Eye Model for Studying Diffusion of Acylcarnitines with Different Physicochemical Properties.

To explore the diffusion capacities between the anterior and vitreous chambers in a novel pig eye model using a mix of stable isotope-labeled acylcarnitines representing metabolites with different physical and chemical properties, and analysis using mass spectrometry (MS). Enucleated pig eyes were injected in the anterior or vitreous chamber of the eye with a stable isotope-labeled acylcarnitine mix (free carnitine, C2, C3, C4, C8, C12, and C16-having an increasing size and hydrophobicity in that order). Samples were collected from each chamber at 3, 6, and 24 h postincubation for analysis using MS.

Electronic Structure of Colloidal 2H-MoS Mono and Bilayers Determined by Spectroelectrochemistry.

The electronic structure of mono and bilayers of colloidal 2H-MoS nanosheets synthesized by wet-chemistry using potential-modulated absorption spectroscopy (EMAS), differential pulse voltammetry, and electrochemical gating measurements is investigated. The energetic positions of the conduction and valence band edges of the direct and indirect bandgap are reported and observe strong bandgap renormalization effects, charge screening of the exciton, as well as intrinsic n-doping of the as-synthesized material. Two distinct transitions in the spectral regime associated with the C exciton are found, which overlap into a broad signal upon filling the conduction band.

Human urinary and blood toxicokinetics of beryllium after accidental exposure.

Purpose: Beryllium is known to have adverse health effects and is classified as carcinogenic to humans. However, data on systemic beryllium exposure in humans are rare and especially human toxicokinetics are largely uncharted. As such, the first reported multi-annual course of blood and urine concentrations after a high exposure scenario provides important new insights.