Application of enzyme matrix values for energy and nutrients to a wheat-corn-soybean meal-based broiler diet supplemented with a novel phytase, with or without a xylanase-β-glucanase, achieved a production benefit over a nutritionally adequate unsupplemented diet.

The effect of applying an energy and nutrient matrix to a wheat-corn-soybean meal-based diet supplemented with a novel consensus bacterial 6-phytase variant (PhyG) and xylanase-β-glucanase on growth performance, bone mineralization, carcass weights, feed costs, and carbon footprint was evaluated. A randomized complete block design (3,300 Ross 308 mixed-sex birds; 60 pens, 12 pens per treatment) tested 5 treatments: 1) a positive control diet (PC), containing 0.92, 0.

Acute physiological responses to a pyramidal exercise protocol and the associations with skin temperature variation in different body areas.

This study aimed to examine the skin temperature (Tsk) variations in five regions of interest (ROI) to assess whether possible disparities between the ROI's Tsk could be associated with specific acute physiological responses during cycling. Seventeen participants performed a pyramidal load protocol on a cycling ergometer. We synchronously measured Tsk in five ROI with three infrared cameras.

An exploratory, intra- and interindividual comparison of the deep neural network automatically measured calf surface radiation temperature during cardiopulmonary running and cycling exercise testing: A preliminary study.

Non-invasive and contactless infrared thermography (IRT) measurements have been claimed to indicate acute neural, cardiovascular, and thermoregulatory adaptations during exercise. Due to challenging comparability, reproducibility, and objectivity, investigations considering different exercise types and intensities, and automatic ROI analysis are currently needed. Thus, we aimed to examine surface radiation temperature (T) variations during different exercise types and intensities in the same individuals, ROI, and environmental conditions.

Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention.

Background: Impaired respiratory and intestinal microbiome composition is linked to cystic fibrosis lung disease severity. In people with cystic fibrosis (pwCF), regular exercise is recommended to delay disease progression and preserve a stable lung function. An optimal nutritional status is vital for best clinical outcomes.

Towards Exercise Radiomics: Deep Neural Network-Based Automatic Analysis of Thermal Images Captured During Exercise.

Infrared thermography is increasingly applied in sports science due to promising observations regarding changes in skin's surface radiation temperature ( T) before, during, and after exercise. The common manual thermogram analysis limits an objective and reproducible measurement of T. Previous analysis approaches depend on expert knowledge and have not been applied during movement.

Association of Innate and Acquired Aerobic Capacity With Resilience in Healthy Adults: Protocol for a Randomized Controlled Trial of an 8-Week Web-Based Physical Exercise Intervention.

Background: Physical activity alleviates chronic stress. The latest research suggests a relationship between resilience and physical fitness. Beneficial adaptations of the hypothalamic-pituitary-adrenal axis, sympathetic nervous system, endocannabinoid system, and tryptophan pathway, which are induced by an active lifestyle, are considered to be conducive to resilience.

Feasibility and implementation of a personalized, web-based exercise intervention for people with cystic fibrosis for 1 year.

Background: Regular participation in exercise is important for people with cystic fibrosis (CF). Therefore, we implemented a personalized, web-based exercise intervention over the course of one year for people with CF. The aims were to investigate the feasibility of the intervention and to evaluate changes in exercise participation, lung function, and exercise capacity.

Kinetics and Topology of DNA Associated with Circulating Extracellular Vesicles Released during Exercise.

Although it is widely accepted that cancer-derived extracellular vesicles (EVs) carry DNA cargo, the association of cell-free circulating DNA (cfDNA) and EVs in plasma of healthy humans remains elusive. Using a physiological exercise model, where EVs and cfDNA are synchronously released, we aimed to characterize the kinetics and localization of DNA associated with EVs. EVs were separated from human plasma using size exclusion chromatography or immuno-affinity capture for CD9, CD63, and CD81 EVs.

Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN.

We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.

Use of a Perioperative Web-Based Exercise Program for a Patient with Barrett's Carcinoma Scheduled for Esophagectomy.

A poor preoperative functional capacity increases the perioperative risk. Therefore, a web-based exercise approach has been initiated for a careful supervision and individual support of patients during their perioperative cancer therapy. Here, we present the data of a 57-year-old patient, scheduled for esophagectomy.

Infrared Thermography in Exercise Physiology: The Dawning of Exercise Radiomics.

Infrared thermography (IRT) is a non-invasive tool to measure the body surface radiation temperature (T). IRT is an upcoming technology as a result of recent advancements in camera lenses, detector technique and data processing capabilities. The purpose of this review is to determine the potential and applicability of IRT in the context of dynamic measurements in exercise physiology.

A patient-specific cerebral blood flow model.

In clinical practice, many complex choices in treatment of complex cerebrovascular diseases have to be made. A patient-specific mathematical blood flow could aid these decisions. For certain cases, less accuracy is required and more simplistic models might be feasible.

Restoring Ventilatory Control Using an Adaptive Bioelectronic System.

Ventilatory pacing by electrical stimulation of the phrenic nerve or of the diaphragm has been shown to enhance quality of life compared to mechanical ventilation. However, commercially available ventilatory pacing devices require initial manual specification of stimulation parameters and frequent adjustment to achieve and maintain suitable ventilation over long periods of time. Here, we have developed an adaptive, closed-loop, neuromorphic, pattern-shaping controller capable of automatically determining a suitable stimulation pattern and adapting it to maintain a desired breath-volume profile on a breath-by-breath basis.

Branching Pattern of the Cerebral Arterial Tree.

Quantitative data on branching patterns of the human cerebral arterial tree are lacking in the 1.0-0.1 mm radius range.

An IC-based controllable stimulator for respiratory muscle stimulation investigations.

Functional Electrical Stimulation can be used to restore motor functions loss consecutive to spinal cord injury, such as respiratory deficiency due to paralysis of ventilatory muscles. This paper presents a fully configurable IC-centered stimulator designed to investigate muscle stimulation paradigms. It provides 8 current stimulation channels with high-voltage compliance and real-time operation capabilities, to enable a wide range of FES applications.

Bio-Inspired Controller on an FPGA Applied to Closed-Loop Diaphragmatic Stimulation.

Cervical spinal cord injury can disrupt connections between the brain respiratory network and the respiratory muscles which can lead to partial or complete loss of ventilatory control and require ventilatory assistance. Unlike current open-loop technology, a closed-loop diaphragmatic pacing system could overcome the drawbacks of manual titration as well as respond to changing ventilation requirements. We present an original bio-inspired assistive technology for real-time ventilation assistance, implemented in a digital configurable Field Programmable Gate Array (FPGA).

Effects of spinal cord injury-induced changes in muscle activation on foot drag in a computational rat ankle model.

Spinal cord injury (SCI) can lead to changes in muscle activation patterns and atrophy of affected muscles. Moderate levels of SCI are typically associated with foot drag during the swing phase of locomotion. Foot drag is often used to assess locomotor recovery, but the causes remain unclear.

Joint-specific changes in locomotor complexity in the absence of muscle atrophy following incomplete spinal cord injury.

Background: Following incomplete spinal cord injury (iSCI), descending drive is impaired, possibly leading to a decrease in the complexity of gait. To test the hypothesis that iSCI impairs gait coordination and decreases locomotor complexity, we collected 3D joint angle kinematics and muscle parameters of rats with a sham or an incomplete spinal cord injury.

Methods: 12 adult, female, Long-Evans rats, 6 sham and 6 mild-moderate T8 iSCI, were tested 4 weeks following injury.

Accelerating locomotor recovery after incomplete spinal injury.

A traumatic spinal injury can destroy cells, irreparably damage axons, and trigger a cascade of biochemical responses that increase the extent of injury. Although damaged central nervous system axons do not regrow well naturally, the distributed nature of the nervous system and its capacity to adapt provide opportunities for recovery of function. It is apparent that activity-dependent plasticity plays a role in this recovery and that the endogenous response to injury heightens the capacity for recovery for at least several weeks postinjury.

Symposium on 'Adaptations of cells and tissues to mechanical stimuli' or 'Roux revisited' held during the Joint Meeting of the Anatomical Society of Great Britain and Ireland, the Anatomical Society of Southern Africa and the Nederlandse Anatomen Vereniging, April 15-18 1998, Rolduc, The Netherlands.

In 1895, well over 100 years ago, Willem Roux published his collected works on the developmental mechanics of organisms in 2 volumes. Volume 1 is largely dedicated to functional adaptation and is a condensation of his investigations into causes of the size and shape of organs and tissues, postulating the influence of functional demand, mediated by mechanical stimuli, on the shaping of organs and tissues. In this classic work he contributed to the understanding of the control of the structural development and organisation of blood vessels, muscles and bone.

Effect of left ventricular assist device outflow conduit anastomosis location on flow patterns in the native aorta.

Computational fluid dynamics (CFD) models were developed to investigate the altered fluid dynamics of the native aorta in patients with a left ventricular assist device (LVAD). The objective of this study was to simulate the effect of LVAD aortic outflow conduit location on the 3-D flow in the native aorta over a range of boundary conditions. The fluid mechanics of three different surgical geometries [(P), proximal, (D), distal and (IP), in-plane] were studied and the implications for short- and long-term medical consequences explored by evaluating the flow fields, wall shear, and hemolysis.

Surgical anatomy of the medial collateral ligament and the posteromedial capsule of the knee.

The supporting structures on the medial side of the knee consist of a superficial fascial layer (I), a deep capsular layer (III) with the deep medial collateral ligament in it and in between the superficial collateral ligament (layer II). The attachment sites of the different ligaments and the functions of the various ligamentous structures are described and suggestions for surgical repair are given.

Visible Human 2.0--the next generation.

The National Library of Medicine has initiated the development of new anatomical methods and techniques for the acquisition of higher resolution data sets, aiming to address the anatomical artifacts encountered in the development of the Visible Human Male and Female and to insure enhanced detection of structures, providing data in greater depth and breadth. Given this framework, we acquired a complete data set of the head and neck. CT and MR scans were also obtained with registration hardware inserted prior to imaging.

Sensory and associated reactions to mineral dusts: sodium borate, calcium oxide, and calcium sulfate.

Occupational exposure limits (OELs) for irritant dusts have had no quantifiable bases. This study (1) charted chemosensory feel, denoted chemesthesis here, to dusts of calcium oxide (1 to 5 mg/m(3)), sodium tetraborate pentahydrate [sodium borate] (5 to 40 mg/m(3)), and calcium sulfate (10 to 40 mg/m(3)); (2) examined correlates of the chemesthetic sensations; and (3) sought to illuminate the basis for potency. Twelve screened men exercised against a light load while they breathed air in a dome fed with controlled levels of dust for 20 min.

Effect of LVAD outflow conduit insertion angle on flow through the native aorta.

Background And Aim: The goal of this study was to evaluate the effect of surgical anastomosis configuration of the aortic outflow conduit (AOC) from a continuous flow left ventricular assist device (LVAD) on the flow fields in the aorta using CFD simulations. The geometry of the surgical integration of the LVAD is an important factor in the flow pattern that develops both in series (aortic valve closed, all flow through LVAD) and in parallel (heart pumping in addition to LVAD).

Methods: CFD models of the AOC junctions simulate geometry as cylindrical tubes that intersect at angles ranging from 30 degrees to 90 degrees.