Publications by authors named "Hillary Maillet"
Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have not detected changes in ChE distribution associated with AD pathology. Probes are typically screened using spectrophotometric methods with pure enzyme for specificity and kinetics.
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- Dysregulation of DNA methylation in breast cancers highlights the potential of DNA demethylating therapies, like decitabine, particularly for treating triple-negative breast cancers (TNBC).
- In a study of 10 breast cancer cell lines, sensitivity to decitabine varied, but was linked to high levels of deoxycytidine kinase (DCK), with TNBCs showing elevated DCK levels that persisted or increased after chemotherapy.
- Gene analysis revealed that decitabine's effectiveness is independent of certain methylation patterns or viral mimicry responses, and it remains effective even in chemoresistant cells, making it a promising second-line treatment option for these patients.