Therapeutic potential of Indonesian plant extracts in combating malaria and protozoan neglected tropical disease.

Background: Neglected tropical diseases (NTDs) afflict nearly 2 billion people worldwide and are caused by various pathogens, such as bacteria, protozoa, and trypanosoma, prevalent in tropical and subtropical regions. Among the 17 NTDs recognized by the World Health Organization (WHO), protozoal infections caused by Plasmodium, Entamoeba, Leishmania, and Trypanosoma are particularly prominent and pose significant public health. Indonesia, endowed with a rich biodiversity owing to its tropical climate, harbors numerous plant species with potent biological activities that hold promise for therapeutic interventions.

Three novel dihydrochalcones from (L.) W.T. Aiton and their antiplasmodial activity.

Three novel dihydrochalcones, flemilineatins C-E (), and two known flavanones () were isolated from (L.) W.T.

Three new dihydrochalcones from the leaves of Jarrett and their activity against .

Three new dihydrochalcones: artoserichalcone A-C (), were isolated from the leaves of . The structures of compounds were determined based on NMR spectrum (H, C, and 2D) and HRESIMS spectroscopic analysis. Compounds () and () showed active antimalarial activity with IC values of 16.

stem bark exhibited antimalarial activity by Lactate Dehydrogenase (LDH) assay.

Objectives: The antimalarial drug resistance is an obstacle in the effort to overcome malaria. The new alternative antimalarial drug became in great attention of urgent need. Current antimalarial drugs were derived from plants.

stem bark contains antimalarial substances against .

Objectives: The finding of alternative medicine for malarial treatment still has become a substantial demand. The plant is one of the potential sources of drugs, among other natural sources. Artocarpus species showed great potential as the antimalarial source.

antimalarial activity of Miq. Stem extracts and fractions on lactate dehydrogenase (LDH) assay.

Objectives: The rapid spread of antimalarial drug resistance is becoming a problem in the treatment of malaria. The fact was indicated the importance of finding new antimalarial drugs. The genus Garcinia is well known to be a rich source of bioactive prenylated xanthones and triterpenes reported for their antimalarial activity.

Safety evaluation of an antimalarial herbal product from (AS201-01) in healthy volunteers.

Objectives: tablets (AS201-01) have previously been shown to have potent bioactivity as an antimalarial and to produce no unwanted side effects in animal models. Here, we present the phase 1 clinical trial conducted to evaluate the safety of AS201-01 tablets in healthy volunteers.

Methods: The study was a randomized, double-blind controlled cross-over, a placebo-controlled design consisting of a 4-day treatment of AS201-01 tablets.

Activities of (AS201-01) Tablet on Cox-2 and Prostaglandin Expression of Placental of Infected Mice.

Background: Placental malaria has ability to upregulate prostaglandin synthesis by increasing cyclooxygenase-2 (Cox-2) enzyme activity. Cox-2 and prostaglandin have a role in causing uterine contraction and therefore can cause abortion or preterm labor. Tablet AS201-01 containing the ethyl acetate fraction of was tested in vivo on pregnant mice infected with .

Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of in Animal Models.

Objectives: To determine the analgesic and antipyretic activities of a tablet derived from ethyl acetate fraction (AS201-01) in animal models.

Methods: The tablet derived from AS201-01 contains an equivalent of 35 mg andrographolide per tablet. Analgesic activity was determined using an acetic acid-induced writhing test on adult male mice.

A tablet derived from complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice.

Objectives: The use of standard antimalarial drugs, such as dihydroartemisinin-piperaquine (DHP) for the treatment of malaria during pregnancy is limited due to the risk of teratogenicity. The alternative is therefore required although few exist. Here we show a phytopharmaceutical drug derived from (AS201-01), which is effective as herbal antimalarial both and and may be a suitable alternative when used in complementary treatment with DHP.