Publications by authors named "Hilit Levy"
Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by microangiopathy, immune dysregulation, and progressive fibrosis of the skin and internal organs. Though not fully understood, the pathogenesis of SSc is dominated by microvascular injury, endothelial dysregulation, and immune response that are thought to be associated with fibroblast activation and related fibrogenesis. Among the main clinical subsets, diffuse SSc (dSSc) is a progressive form with rapid and disseminated skin thickening accompanied by internal organ fibrosis and dysfunction.
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- Cerebrovascular amyloidosis, caused by amyloid buildup in blood vessel walls, can result in hemorrhagic strokes and cognitive decline, starting from as early as 7 months in genetically modified mice.
- Researchers found that scavenger receptor A (SRA) on macrophages is crucial for clearing cerebrovascular amyloid, as SRA-deficient mice showed symptoms at just 3 months of age, compared to 7 months in normal mice.
- This study highlights the potential of targeting SRA in future treatments for conditions like cerebral amyloid angiopathy, emphasizing its role in managing amyloid-related vascular issues.