The DIVE/DPV registries: evolution of empagliflozin use in clinical practice in Germany.

Introduction: Empagliflozin reduced morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) in clinical trials. A registry study was undertaken to describe evolution of patient characteristics and assess the real-world effectiveness/safety of empagliflozin.

Research Design And Methods: Data from the Diabetes Patienten Verlaufsdokumentation (DPV)/Diabetes Versorgungsevaluation (DIVE) registries on 9571 adults with T2DM (registered in 2014-2019) receiving empagliflozin were used.

Detection of novel biomarkers for ovarian cancer with an optical nanotechnology detection system enabling label-free diagnostics.

Ovarian carcinoma has the highest lethality rate of gynecologic tumors, largely attributed to the late-stage diagnosis of the disease. Reliable tools for both accurate diagnosis and early detection of disease onset are lacking, and presently less than 20% of ovarian cancers are detected at an early stage. Protein biomarkers that allow the discrimination of early and late stages of ovarian serous carcinomas are urgently needed as they would enable monitoring pre-symptomatic aspects of the disease, disease progression, and the efficacy of intervention therapies.

Effects of dilution and prolonged storage with preservative in a polyethylene container on Bevacizumab (Avastin™) for topical delivery as a nasal spray in anti-hereditary hemorrhagic telangiectasia and related therapies.

Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia and severe, recurrent epistaxis is a common clinical phenotype associated with HHT. An intranasal treatment regime of diluted Avastin™ (Bevacizumab; recombinant humanized anti-vascular epithelial growth factor immunoglobin G1) using apulsatile nasal irrigator has proven efficacious in clinical practice. However, concerns regarding the stability of Avastin™ following dilution and prolonged storage in standard containers used for drug delivery, such as polyethylene bottles, have so far prevented a more widespread clinical use.

A smoking cessation intervention for thoracic surgery and oncology clinics: a pilot trial.

Introduction: Although most smokers diagnosed with lung cancer report that they want to quit smoking, many do not succeed. Smokers who quit when lung cancer is diagnosed have improved treatment efficacy, quality of life, and survival. Effective smoking cessation interventions targeted to thoracic oncology patients are needed.

Polycystin-2 expression and function in adult mouse lacrimal acinar cells.

Purpose: Lacrimal glands regulate the production and secretion of tear fluid. Dysfunction of lacrimal gland acinar cells can ultimately result in ocular surface disorders, such as dry eye disease. Ca(2+) homeostasis is tightly regulated in the cellular environment, and secretion from the acinar cells of the lacrimal gland is regulated by both cholinergic and adrenergic stimuli, which both result in changes in the cytosolic Ca(2+) concentration.

Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.

Dysregulation of Ca(2+) signaling following oxidative stress is an important pathophysiological mechanism of many chronic neurodegenerative disorders, including Alzheimer's disease, age-related macular degeneration, glaucomatous and diabetic retinopathies. However, the underlying mechanisms of disturbed intracellular Ca(2+) signaling remain largely unknown. We here describe a novel mechanism for increased intracellular Ca(2+) release following oxidative stress in a neuronal cell line.

[Iatrogenic femoral pseudoaneurysm--an urgent surgical indication].

Fifteen patients with an aneurysma spurium of the femoral artery due to coronary angiography had to be operated from March, 1988 till April, 1990. Contrary to our expectations we did not find a culmination of risk factors or relevant arteriosclerosis of the legs in these patients. It were the "young vessels" that were not able to compensate the defects from catheters and locks.

[ECG changes following balloon dilatation of pulmonary valve stenoses].

To evaluate the role of electrocardiography in the long-term follow up of children after balloon valvuloplasty of pulmonary stenosis the ECG findings of ten children (4 girls and 6 boys) with a mean age of 7.8 +/- 3.3 years who underwent valvuloplasty of pulmonary stenosis were studied.

Systemic vascular responses to atracurium during enflurane-nitrous-oxide anesthesia in humans.

Systemic circulatory responses to atracurium (0.2 and 0.4 mg/kg) were studied in 15 healthy (ASA I or II) adult patients during enflurane (1.

Effect of propranolol on circulatory responses to induction of diazepam-nitrous oxide anesthesia and to endotracheal intubation.

The present study evaluated the hemodynamic effects produced by the intravenous infusion of diazepam (0.5 mg/kg over 10 minutes) and the simultaneous inhalation of 50% nitrous oxide in oxygen administered to 19 patients with coronary artery disease who were receiving chronic propranolol therapy (106 +/- 67 mg/day). In addition, hemodynamic changes produced by direct laryngoscopy and intubation of the trachea were measured.

Characteristics of succinylcholine-produced phase II neuromuscular block during enflurane, halothane, and fentanyl anesthesia.

The characteristics of phase II neuromuscular block following repeated intravenous injections of succinylcholine (SCh) were determined in 15 adult patients during enflurane, halothane, or fentanyl-nitrous oxide anesthesia. The onset of phase II block (train-of-four ratio (T4) equal to 0.5) occurred following a cumulative SCh dose of 4.

Hemodynamic effects of diazepam and diazepam-nitrous oxide in patients with coronary artery disease.

Circulatory responses following intravenous diazepam (0.5 mg/kg) and the subsequent addition of 50% nitrous oxide were studied in 14 patients undergoing elective aortocoronary saphenous vein bypass operations. No patient was receiving propranolol.

Pulmonary and systemic vascular responses to nitrous oxide in patients with mitral stenosis and pulmonary hypertension.

Pulmonary and systemic circulatory responses to inhalation of 50% nitrous oxide were studied in 11 patients with pulmonary hypertension prior to elective mitral valve replacement. All patients were premedicated with intramuscular morphine and scopolamine. Compared with awake control measurements while breathing 50% oxygen in nitrogen, heart rate, cardiac index, systemic and pulmonary vascular pressures, systemic vascular resistance, and systemic and pulmonary heart rate, systolic blood pressure products remained unchanged after administration of 50% nitrous oxide for 10 minutes.