Publications by authors named "Hilde Room"
Tissue Eng Part A
October 2017
Article Synopsis
- Macrophages play a key role in the foreign body reaction (FBR) by creating a proinflammatory environment and helping to degrade biomaterials, while also signaling fibroblasts to form a fibrous capsule around implants.
- In an experiment using mice with controllable macrophage depletion, it was found that removing macrophages stopped inflammation from infiltrating collagen scaffolds and increased the size of the fibrous capsule.
- The study showed that while macrophages are essential for fostering inflammation around implants, they may actually limit the production of certain growth factors and collagens in the fibrous capsule formed by fibroblasts.
