Publications by authors named "Hilda M Gonzalez-Sanchez"
Insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) are signaling adaptor proteins that participate in canonical pathways, where insulin cascade activation occurs, as well as in non-canonical pathways, in which phosphorylation of substrates is carried out by a diverse array of receptors including integrins, cytokines, steroid hormones, and others. IRS proteins are subject to a spectrum of post-translational modifications essential for their activation, encompassing phosphorylation events in distinct tyrosine, serine, and threonine residues. Tyrosine residue phosphorylation is intricately linked to the activation of the insulin receptor cascade and its interaction with SH2 domains within a spectrum of proteins, including PI3K.
View Article and Find Full Text PDFZika virus (ZIKV) was first isolated in 1947. From its isolation until 2007, symptoms of ZIKV-caused disease were limited (e.g.
View Article and Find Full Text PDFExosomes are extracellular vesicles derived from the endosomal compartment, which are released by all kinds of eukaryotic and prokaryotic organisms. These vesicles contain a variety of biomolecules that differ both in quantity and type depending on the origin and cellular state. Exosomes are internalized by recipient cells, delivering their content and thus contributing to cell-cell communication in health and disease.
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- A study was conducted in a Covid-19 hospital in Morelos, Mexico, to assess the prevalence of SARS-CoV-2 antibodies among healthcare workers (HCW) and identify factors linked to infection.
- The findings revealed that 31% of participants had antibodies, while only 13.1% had tested positive via RT-PCR, with higher seroprevalence seen in social workers (35.7%) compared to laboratory personnel (12.0%).
- The study emphasizes the value of serological testing for accurately assessing infection rates in healthcare settings where only symptomatic cases are typically documented.
Article Synopsis
- Myeloid cells, specifically macrophages, play a crucial role in regulating inflammation in synovial joints, particularly in rheumatoid arthritis, where the molecule IL-34 is significantly expressed.
- IL-34 interacts with a newly identified receptor called PTPRZ found on macrophages, and their absence in specific mouse models led to more severe arthritis symptoms.
- IL-34 and PTPRZ work to promote a reparative macrophage phenotype, enhancing the clearance of dying neutrophils and reducing their recruitment to the inflamed joint, ultimately limiting destructive inflammation and joint damage.
Background: In people with SLE and in the MRL- lupus mouse model, macrophages and autoantibodies are central to lupus nephritis. IL-34 mediates macrophage survival and proliferation, is expressed by tubular epithelial cells (TECs), and binds to the cFMS receptor on macrophages and to a newly identified second receptor, PTPRZ.
Methods: To investigate whether IL-34-dependent intrarenal and systemic mechanisms promote lupus nephritis, we compared lupus nephritis and systemic illness in MRL- mice expressing IL-34 and IL-34 knockout (KO) MRL- mice.
Apoptosis is one of the most effective mechanisms against the spread of pathogens such as viruses. However, viruses have developed measures to counter the protective role of apoptosis in infected cells. Cytomegalovirus (CMV) represents the major cause of congenital infection worldwide triggering important damage in the developing central nervous system (CNS).
View Article and Find Full Text PDFObjective: Cytomegalovirus (CMV) is widely distributed and constitutes the main cause of congenital infections worldwide. CMV transmission during pregnancy represents one of the major impacts of this virus on public health. This study aimed at assessing glycoprotein B (gB) CMV genotypes in Mexican children and pregnant women, since there is limited information regarding CMV genomic diversity in Mexico.
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