Associations between media use at bedtime and sleep: a cross-sectional analysis on differences between girls and boys.

Objectives: This study investigated associations between the use of electronic media and sleep in children and young adolescents, with a specific focus on the moderation of associations by sex and age.

Methods: Between 2021 and 2022, 453 10- to 14-year-old children participating in the LIFE Child cohort study (Germany) reported on their use of electronic media (daily screen time, use at bedtime, device ownership) and on their sleep difficulties (Sleep Self Report). Associations between media use and sleep as well as interactions with age and sex were assessed using linear regression analyses.

Five-Year Follow-Up of Diabetic Complications and Geriatric Alterations in French Older Patients with Type 2 Diabetes According to Treatment Modalities: The Observational Prospective GERODIAB Cohort.

Background: Little is known about clinical events occurring in older patients with type 2 diabetes mellitus according to their therapeutic modalities based on the prescription of insulin and/or oral antidiabetic drugs.

Objective: The aim of this study was to compare the complications of diabetes and geriatric alterations that occurred according to three therapeutic modalities prescribed over 5 years.

Methods: A total of 616 patients from the GERODIAB cohort (mean age 77.

Species-Specific Responses to Human Trampling Indicate Alpine Plant Size Is More Sensitive than Reproduction to Disturbance.

Human disturbance, such as trampling, is an integral component of global change, yet we lack a comprehensive understanding of its effects on alpine ecosystems. Many alpine systems are seeing a rapid increase in recreation and in understudied regions, such as the Coast Mountains of British Columbia, yet disturbance impacts on alpine plants remain unclear. We surveyed disturbed (trail-side) and undisturbed (off-trail) transects along elevational gradients of popular hiking trails in the T'ak't'ak'múy'in tl'a In'inyáxa7n region (Garibaldi Provincial Park), Canada, focusing on dominant shrubs (, ) and graminoids ( spp).

Pharmacoepidemiological Analysis of Oral Contraceptive Use in Adolescents in a German Longitudinal Cohort Study.

To assess the use of oral contraceptives (OC) in adolescents, using data from a longitudinal, population-based pediatric cohort study (LIFE Child). We also investigated associations between OC use and socioeconomic status (SES), and associations between OC use and potential adverse drug reactions such as effects on blood pressure. We included 609 female participants of the LIFE Child cohort, aged ≥13 to <21 years, who visited the study center between 2012 and 2019.

[Further Development of Maturity Levels of Quality and Risk Management System at the University Hospital Schleswig-Holstein].

Introduction: Following upon our publication "Maturity Levels of Quality and Risk Management at the University Hospital Schleswig-Holstein" in 2018, we present the further development of the maturity model. Quality and risk management in hospitals is not only required by law but also plays a significant role in an optimized patient- and process-oriented health care.

Methods: A questionnaire-based self-assessment was carried out by 46 clinical units of the UKSH (location Kiel and Lübeck) for the analysis of nine quality criteria overall.

Concentrations of oligosaccharides in human milk and child growth.

Background: The relationship between human milk oligosaccharides (HMO) and child growth has been investigated only insufficiently with ambiguous results. Therefore, this study examines potential influencing factors of HMO concentrations and how HMO are associated with child growth parameters.

Methods: Milk samples from the German LIFE Child cohort of healthy children were analyzed for 9 HMO.

Atopic diseases in children and adolescents are associated with behavioural difficulties.

Background: Atopic diseases and behavioural difficulties in children have both been on the rise in recent decades. This study seeks to assess associations between atopic diseases and behavioural difficulties, examining the differences considering child age and how behavioural difficulties were reported (via self-report or parent-report).

Methods: Data on behavioural difficulties, assessed through the Strengths and Difficulties Questionnaire (SDQ), and on atopic diseases, assessed through the participant's medical history, were available for 2701 study participants aged 3 to 18 years.

"Other minds than ours": a controversial discussion on the limits and possibilities of comparative psychology in the light of C. Lloyd Morgan's work.

C. Lloyd Morgan is mostly known for Morgan's canon (An introduction to comparative psychology, Walter Scott, Limited, London, 1894), still a popular and frequently quoted principle in comparative psychology and ethology. There has been a fair amount of debate on the canon's interpretation, function, and value regarding the research on animal minds, usually referring to it as an isolated principle.

[Maturity Levels of Quality and Risk Management at the University Hospital Schleswig-Holstein].

Introduction: Quality and risk management in hospitals are not only required by law but also for an optimal patient-centered and process-optimized patient care. To evaluate the maturity levels of quality and risk management at the University Hospital Schleswig-Holstein (UKSH), a structured analytical tool was developed for easy and efficient application.

Methods: Four criteria concerning quality management - quality assurance (QS), critical incident reporting system (CIRS), complaint management (BM) and process management (PM) - were evaluated with a structured questionnaire.

Nurses' Perceptions of In-Hospital Versus Telephone Availability of an Intensivist at Night in an Intensive Care Unit.

Background: Evidence suggests that in-person management by nighttime intensivists does not change patients' mortality rates in high-intensity intensive care units.

Objective: To better understand domains affected by nighttime intensivist staffing not previously measured.

Methods: Semistructured interviews of 13 night-shift nurses in an academic medical intensive care unit to elicit perceptions of nighttime staffing with attending intensivists versus residents with attending intensivists on call remotely.

HIV testing in an ethnically diverse sample of American university students: associations with violence/abuse and covariates.

Associations linking HIV infection to violence and abuse are well documented; however, little is known about how violence/abuse is related to HIV testing behavior, particularly among undergraduate university students, who test at lower rates compared to non-student peers in the United States. We assessed history of HIV testing in an ethnically diverse sample of undergraduates in California (n = 1,210); and examined potential associations between testing and various forms of violence/abuse, while controlling for covariates. Whereas 73.

[Early results with a monorail-stent-balloon device for endovascular treatment of renal artery stenosis].

Objective: To evaluate the technical feasibility of a new monorail-stent-balloon device for treatment of renal artery stenosis (RAS).

Patients And Methods: During a study period of 18 months, 38 patients with proven RAS in 41 cases (hypertension n = 36, renal insufficiency n = 13) and indication for stenting (calicified ostial lesions n = 35, insufficient PTA n = 4, dissection n = 2) were enrolled into this prospective evaluation. Pre-mounted stents (Rx-Herculink(TM) 5 mm = 13, 6 mm = 34, 7 mm = 1) were implanted a transfemoral (n = 35) or transbrachial approach (n = 6).

Interactions of HLA-B27 with the peptide loading complex as revealed by heavy chain mutations.

MHC class I heavy chains assemble in the endoplasmic reticulum with beta(2)-microglobulin and peptide to form heterotrimers. Although full assembly is required for stable class I molecules to be expressed on the cell surface, class I alleles can differ significantly in their rates of, and dependencies on, full assembly. Furthermore, these differences can account for class I allele-specific disparities in antigen presentation to T cells.

Randomized study to compare PTA alone versus PTA with Palmaz stent placement for femoropopliteal lesions.

Purpose: The purpose of this study was to evaluate whether percutaneous transluminal angioplasty (PTA) combined with Palmaz stent placement provides long-term advantages compared to PTA alone after 34 months of follow-up in the femoropopliteal region.

Materials And Methods: Thirty patients randomized to undergo PTA in combination with stent placement and 23 patients randomized to undergo PTA alone were evaluated.

Results: Mean follow-up (+/-SD) for the PTA group was 33.

[First results after implantation of the new balloon-expanded Bridge-Stent into the iliac artery].

Purpose: To determine the success and patency rates of the new, balloon-expandable Bridge-stents for treatment of occlusions and stenoses of iliac arteries.

Material And Methods: Between April and October 1999, 21 patients suffering from peripheral arterial occlusive disease were treated (22 lesions). In 20 cases high-grade stenoses and in two cases complete occlusions were treated.

[Mid-term follow-up after placement of the new balloon-expendable VIP-stent into the iliac arteries].

Purpose: To assess the effectiveness and mid-term patency of VIP balloon expandable stents in patients with iliac occlusive disease.

Material And Methods: Between August and December 1997, 26 balloon-expandable VIP (Medtronic) stainless steel vascular stents were implanted in 19 patients with iliac occlusive disease. 22 lesions in common iliac (n = 11), external iliac (n = 5), common iliac plus contralateral external iliac (n = 1), and unilateral common and external iliac (n = 2) arteries were stented, allowing 20 limbs for assessment.

Mechanical thrombectomy of acute thrombosis in transjugular intrahepatic portosystemic shunts.

Rationale And Objectives: To evaluate the feasibility of mechanical thrombectomy with the use of the Amplatz thrombectomy device (ATD) in restoring patency to acutely thrombosed stent-shunts after transjugular intrahepatic portosystemic shunt (TIPS) placement.

Methods: Mechanical thrombectomy with the ATD was performed in 10 consecutive patients with angiographically documented complete thrombosis of the stent-shunt (mean +/- SD, 6.6 +/- 3.

Definition and transfer of a serological epitope specific for peptide-empty forms of MHC class I.

Nascent class I molecules have been hypothesized to undergo a conformational change when they bind peptide based on the observation that most available antibodies only detect peptide-loaded class I. Furthermore recent evidence suggests that this peptide-facilitated conformational change induces the release of class I from association with transporter associated with antigen processing (TAP)/tapasin and other endoplasmic reticulum proteins facilitating class I assembly. To learn more about the structure of peptide-empty class I, we have studied mAb 64-3-7 that is specific for peptide-empty forms of L(d).

Disparate cytochemical characteristics and production of cytokines and prostaglandin E2 by human mononuclear phagocytes from the blood, lung, and peritoneal cavity.

The cytochemical characteristics and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and prostaglandin E2 (PGE2) by peritoneal macrophages were compared with those of blood monocytes and alveolar macrophages. The comparative percentages of mononuclear phagocytes positive for peroxidase were as follows: blood monocytes > peritoneal macrophages > alveolar macrophages. The comparative percentages of cells positive for nonspecific esterase were as follows: alveolar macrophages > peritoneal macrophages = blood monocytes.

Role of dialysis modality in responses of blood monocytes and peritoneal macrophages to endotoxin stimulation.

Constitutive and endotoxin (lipopolysaccharide [LPS])-stimulated release of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 (PGE2) by blood monocytes and peritoneal cell preparations from patients on various forms of dialysis was measured. Monocytes were obtained from healthy controls (n = 20), and from patients on peritoneal dialysis (n = 8), on hemodialysis with cellulose ester membranes (n = 9), and on hemodialysis with polysulfone membranes (n = 8). Peritoneal macrophages were recovered by lavage during laparoscopic surgery from 11 healthy controls, from dialysate in 37 patients on peritoneal dialysis, and at catheter placement for transfer to peritoneal dialysis from eight patients on hemodialysis with polysulfone membranes.

Potentiation of cardiodepressive action among calcium antagonists from different classes: evidence for a mechanism at the single calcium channel level.

The ability of calcium antagonists and antiarrhythmic agents to potentiate the negative inotropic effects of calcium antagonists was investigated in guinea-pig left atria. The potency of nitrendipine was enhanced by several amphiphilic agents by one order of magnitude or more (by pretreatment with quinidine or bepridil). The effect of preincubation with bepridil was investigated for a larger number of dihydropyridines.